Results 61 to 70 of about 221,563 (313)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine [PDF]

, 2009
BACKGROUND: Variations in the composition of the human intestinal microbiota are linked to diverse health conditions. High-throughput molecular technologies have recently elucidated microbial community structure at much higher resolution than was ...
Vos, W.M., de, Willem M de Vos, O\u27Toole, Paul W., Smidt, H., O'Sullivan, O., Janne Nikkilä, Claesson Marcus J., de Vos Willem M., Hauke Smidt, O'Sullivan, Orla, Marchesi, Julian Roberto, O\u27Sullivan, Orla, Ross R. Paul, Smidt, Hauka, Ross, R. Paul, Ross, R. P., Paul W O'Toole, Wang, Qiong, Orla O'Sullivan, O'Sullivan Orla, de Vos, W.M., Qiong Wang, Nikkilä Janne, O'Toole, Paul W., Claesson, M.J., Marchesi, J.R., O'Toole, P.W., Claesson, Marcus J., O'Toole, P. W., Wang, Q., de Vos, Willem M., Claesson, M. J., Julian R Marchesi, O'Toole Paul W., Marchesi, Julian R., Smidt, Hauke, Ross, R.P., Smidt Hauke, Nikkila, Janne, R Paul Ross, Marchesi Julian R., Ross, R Paul, Wang Qiong, De Vos, W. M., Nikkilä, J., Marcus J Claesson   +45 more
core   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

An iterative workflow for mining the human intestinal metaproteome [PDF]

, 2011
Background Peptide spectrum matching (PSM) is the standard method in shotgun proteomics data analysis. It relies on the availability of an accurate and complete sample proteome that is used to make interpretation of the spectra feasible.
Vos, W.M., de, Schaap, Peter, Willem M de Vos, Peter J Schaap, Boeren, S., Christian Beauvallet, Rooijers, Koos, Juste Catherine, Joël Doré, Doré Joël, Beauvallet, Christian, Been, M., de, Rooijers, K., de Been Mark, Schaap, P.J., Dore, Joel, Pilar Galan, Boeren Sjef, Beauvallet, C., Koos Rooijers, de Vos, W.M., Kolmeder, C., Schaap Peter J, Kolmeder, Carolin, Boeren, Sjef, de Vos, Willem M., de Been, Mark, Catherine Juste, Kolmeder Carolin, Galan, P., Doré, J., Rooijers Koos, Juste, C., Galan, Pilar, Mark de Been, Galan Pilar, Sjef Boeren, Beauvallet Christian, de Vos Willem M, de Vos, Willem, Juste, Catherine, Schaap, Peter J., de Been, M., Carolin Kolmeder   +43 more
core   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Ammonia exposure induced intestinal inflammation injury mediated by intestinal microbiota in broiler chickens via TLR4/TNF-α signaling pathway

Ecotoxicology and Environmental Safety, 2021
Ammonia is a known environmental pollutant that causes injury to the intestine. Growing evidence suggests that intestinal microbiota dysbiosis involves in the development of intestinal injury under environmental pollution. However, the specific mechanism
Ying Zhou, Minhong Zhang, Xin Zhao, Jinghai Feng   +3 more
doaj   +1 more source

Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples

, 2011
Large-scale and in-depth characterization of the intestinal microbiota necessitates application of high-throughput 16S rRNA gene-based technologies, such as barcoded pyrosequencing and phylogenetic microarray analysis.
Vos, W.M., de, Bartholomeus van den Bogert, Kleerebezem, M., van den Bogert, B., Michiel Kleerebezem, Willem M. de Vos, Zoetendal, E.G., Bogert, B., van den, de Vos, W.M., Erwin G. Zoetendal   +9 more
core   +1 more source

Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis [PDF]

, 2015
Eggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment of immune-mediated diseases. In this context, only the infective, embryonated eggs, constitute the Active Pharmaceutical Ingredient (API).
Kapel, Christian M. O., Kapel, Christian Moliin Outzen, Jennifer Keiser, Helene Kringel, Nermina Vejzagić, Adelfio, Roberto, Christian M.O. Kapel, Thamsborg, Stig Milan, Roberto Adelfio, Stig Milan Thamsborg, Keiser, Jennifer, Kringel, Helene, Vejzagić, Nermina   +12 more
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

The Role of the Intestinal Microbiota in Nonalcoholic Steatohepatitis

Frontiers in Endocrinology, 2022
Nonalcoholic steatohepatitis (NASH) is a serious disease threatening public health, and its pathogenesis remains largely unclear. Recent scientific research has shown that intestinal microbiota and its metabolites have an important impact on the ...
Hui Xiang, Hui Xiang, Dating Sun, Xin Liu, Zhi-Gang She, Yonghong Chen   +5 more
doaj   +1 more source