Results 61 to 70 of about 519,517 (262)

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation [PDF]

, 2015
The authors acknowledge the support of the Biotechnology and Biological Sciences Research Council (BBSRC), this research was partly funded by the BBSRC Institute Strategic Programme for The Gut Health and Food Safety (BB/J004529/1) and by the BB/L008602 ...
Vos, W.M., de, Hardy-Goddard, Jemma, Crost, Emmanuelle H., de Vos, Willem M., Gall, G., Le, Taylor, Garry L., Walshaw, J., Tailford, L.E., Crost, E.H., Taylor, G.L., Juge, N., Owen, C.D., Tailford, Louise E., Owen, C. David, Le Gall, G., Le Gall, Gwenaelle, Hardy-Goddard, J., Juge, Nathalie, Walshaw, John, de Vos, W.M.   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Phylogenomic analysis of the collagen-like BclA proteins in Clostridioides difficile

Applied and Environmental Microbiology
Clostridioides difficile is a Gram-positive, anaerobic, spore-forming bacterium and a major nosocomial pathogen, notable for its high genetic diversity. C.
Francisca Cid-Rojas, Enzo Guerrero-Araya, Christian Brito-Silva, Marjorie Pizarro-Guajardo, César Rodríguez, Daniel Paredes-Sabja   +5 more
doaj   +1 more source

Intestinal microbiota and nonalcoholic steatohepatitis [PDF]

Current Opinion in Gastroenterology, 2017
Nonalcoholic fatty liver disease (NAFLD) is a liver disease with high prevalence in western countries. Progression from NAFLD to nonalcoholic steatohepatitis (NASH) occurs in 10-20%. NASH pathogenesis is multifactorial including genetic and environmental factors.
Katharina, Brandl, Bernd, Schnabl
openaire   +2 more sources

The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes [PDF]

, 2011
Background: The human gastrointestinal tract contains a complex community of microbes, fulfilling important health-promoting functions. However, this vast complexity of species hampers the assignment of responsible organisms to these functions. Recently,
Willem M de Vos, Kant Ravi, van Passel, Mark W. J., Mark Van Passel, Zoetendal, Erwin G., Chain, Patrick S. G., de Vos Willem M., Chain Patrick S. G., van Passel Mark W. J., Hauke Smidt, Derrien Muriel, Patrick S G Chain, Derrien, Muriel, Airi Palva, Palva Airi, Derrien, M.M.N., Malfatti, Stephanie A., Woyke, Tanja, Malfatti, S.A., Mark W J van Passel, Caroline M Plugge, Ravi Kant, Tanja Woyke, Kant, R., Muriel Derrien, Smidt, Hauke, Erwin G Zoetendal, Willem M. De Vos, Vos, W.M., de, Smidt, H., Malfatti Stephanie A., Mark W. J. Van Passel, Erwin G. Zoetendal, Plugge Caroline M., Plugge, Caroline M., de Vos, Willem M., Zoetendal, E.G., Stephanie A. Malfatti, Patrick S. G. Chain, Palva, Airi, Smidt Hauke, Plugge, C.M., Caroline M. Plugge, Passel, M.W.J., van, Kant, Ravi, Woyke Tanja, Stephanie A Malfatti, Zoetendal Erwin G., Palva, A.   +48 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The SERPINB4 gene mutation identified in twin patients with Crohn’s disease impaires the intestinal epithelial cell functions

Scientific Reports
Crohn’s disease (CD) is a chronic inflammatory autoimmune disease of unknown etiology. To identify new targets related to the initiation of CD, we screened a pair of twins with CD, which is a rare phenomenon in the Chinese population, for genetic ...
Xiao-Mei Ouyang, Jun-Hui Lin, Ying Lin, Xian-Ling Zhao, Ya‐Ni Huo, Lai-Ying Liang, Yong-Dong Huang, Gui-Jing Xie, Peng Mi, Zhen-Yu Ye, Bayasi Guleng   +10 more
doaj   +1 more source

An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tract of rats [PDF]

, 2012
BACKGROUND: Horizontal gene transfer through natural transformation of members of the microbiota of the lower gastrointestinal tract (GIT) of mammals has not yet been described.
Raddadi Noura, Nielsen KM, Traavik T, Terje Traavik, Brusetti Lorenzo, Averhoff, Beate, Nordgård Lise, Beate Averhoff, Nordgård, Lise, Noura Raddadi, Brusetti L, Nielsen, Kaare Magne, Kaare Magne Nielsen, Traavik, Terje, Nielsen Kaare, Traavik Terje, Lorenzo Brusetti, Raddadi, Noura, Averhoff B, Brusetti, Lorenzo, Averhoff Beate, Nordgård L, Lise Nordgard   +22 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Assessment of chemical methods in the extraction of spore surface layers in Clostridioides difficile spores

mSphere
Clostridioides difficile spores are essential for initiation, recurrence, and transmission of C. difficile infections (CDI). These outermost layers of the spore, the exosporium and spore coat, are responsible for initial interactions with the host and ...
Javier Sanchez, Alba Romero-Rodriguez, Scarlett Troncoso-Cotal, Morgan S. Osborne, Theresa Ariri, Joseph A. Sorg, Daniel Paredes-Sabja   +6 more
doaj   +1 more source