Results 51 to 60 of about 221,563 (313)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phylogenomic analysis of the collagen-like BclA proteins in Clostridioides difficile

Applied and Environmental Microbiology
Clostridioides difficile is a Gram-positive, anaerobic, spore-forming bacterium and a major nosocomial pathogen, notable for its high genetic diversity. C.
Francisca Cid-Rojas, Enzo Guerrero-Araya, Christian Brito-Silva, Marjorie Pizarro-Guajardo, César Rodríguez, Daniel Paredes-Sabja   +5 more
doaj   +1 more source

Intestinal microbiota, obesity and prebiotics [PDF]

Polish Journal of Microbiology, 2015
Over the past few decades there has been a significant increase in the prevalence of obesity in both children and adults. Obesity is a disease that has reached epidemic levels on a global scale. The development of obesity is associated with both environmental and genetic factors.
R, Barczynska, K, Bandurska, K, Slizewska, M, Litwin, M, Szalecki, Z, Libudzisz, J, Kapusniak   +6 more
openaire   +2 more sources

Avaliação da microbiota intestinal e sua relação com parâmetros metabólicos em mulheres com obesidade mórbida [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2014Introdução: A microbiota intestinal refere-se aos micro-organismos que reside no trato ...
Beserra, Bruna Teles Soares
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The SERPINB4 gene mutation identified in twin patients with Crohn’s disease impaires the intestinal epithelial cell functions

Scientific Reports
Crohn’s disease (CD) is a chronic inflammatory autoimmune disease of unknown etiology. To identify new targets related to the initiation of CD, we screened a pair of twins with CD, which is a rare phenomenon in the Chinese population, for genetic ...
Xiao-Mei Ouyang, Jun-Hui Lin, Ying Lin, Xian-Ling Zhao, Ya‐Ni Huo, Lai-Ying Liang, Yong-Dong Huang, Gui-Jing Xie, Peng Mi, Zhen-Yu Ye, Bayasi Guleng   +10 more
doaj   +1 more source

Characteristics and early development of intestinal microbiota in piglets

Siliao yanjiu, 2022
There are dense, dynamic and highly complex microbial communities in pig intestine. Intestinal microbiota plays an important role in promoting intestinal maturation, regulating the immune system, enhancing the health and growth performance of host ...
ZHAO Huai-bao
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Assessment of chemical methods in the extraction of spore surface layers in Clostridioides difficile spores

mSphere
Clostridioides difficile spores are essential for initiation, recurrence, and transmission of C. difficile infections (CDI). These outermost layers of the spore, the exosporium and spore coat, are responsible for initial interactions with the host and ...
Javier Sanchez, Alba Romero-Rodriguez, Scarlett Troncoso-Cotal, Morgan S. Osborne, Theresa Ariri, Joseph A. Sorg, Daniel Paredes-Sabja   +6 more
doaj   +1 more source

The environment within: how gut microbiota may influence metabolism and body composition

, 2010
Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of ...
Vos, W.M., de, A. Vrieze, Hoekstra, J. B. L., E. G. Zoetendal, Zoetendal, E.G., F. Holleman, Vrieze, A., W. M. de Vos, J. B. L. Hoekstra, M. Nieuwdorp, Holleman, F., Zoetendal, E. G., Hoekstra, J.B., de Vos, W. M., de Vos, W.M., Nieuwdorp, M.   +15 more
core   +1 more source