Results 51 to 60 of about 519,517 (262)

Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota.

PLoS ONE, 2021
Non-steroidal anti-inflammatory drugs (NSAIDs) induce small intestinal damage. It has been reported that rebamipide, a mucoprotective drug, exerts a protective effect against NSAID-induced small intestinal damage; however, the underlying mechanism ...
Tetsuya Tanigawa, Toshio Watanabe, Akira Higashimori, Sunao Shimada, Hiroyuki Kitamura, Takuya Kuzumoto, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Masatsugu Shiba, Wataru Suda, Masahira Hattori, Yasuhiro Fujiwara   +17 more
doaj   +1 more source

Multi-target regulation of intestinal microbiota by berberine to improve type 2 diabetes mellitus

Frontiers in Endocrinology, 2022
Type 2 diabetes mellitus (T2DM) and its complications are major public health problems that seriously affect the quality of human life. The modification of intestinal microbiota has been widely recognized for the management of diabetes.
Qiongyao He, Hui Dong, Yujin Guo, Minmin Gong, Qingsong Xia, Fuer Lu, Dingkun Wang   +6 more
doaj   +1 more source

Preterm gut microbiota and metabolome following discharge from intensive care [PDF]

, 2015
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and ...
Skeath, Tom, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Marrs, Emma, Embleton, Nicholas, Fernstad, Sara J., Fernstad, Sara Johansson, Berrington, Janet, Marrs, E. C. L. (Emma), Cummings, Stephen, Perry, John, Skeath, Thomas   +12 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX [PDF]

, 2010
Dynamic, multicompartment in vitro gastrointestinal simulators are often used to monitor gut microbial dynamics and activity. These reactors need to harbor a microbial community that is stable upon inoculation, colon region specific, and relevant to in ...
Marzorati, M., Sam Possemiers, Sahar El Aidy, Kleerebezem, M., Verstraete, Willy, Smidt, H., Marzorati, Massimo, Philippe Gérard, Rabot, S., Charlotte Grootaert, Verstraete, W., Aidy, S.F., El, Erwin Zoetendal, Hauke Smidt, Possemiers, Sam, Zoetendal, Erwin, Kleerebezem, Michiel, van der Wiele, T., Sylvie Rabot, Grootaert, C., Michiel Kleerebezem, Possemiers, S., Massimo Marzorati, Derrien, Muriel, Pieter Van den Abbeele, Tom Van de Wiele, Derrien, M.M.N., Rabot, Sylvie, Grootaert, Charlotte, van den Abbeele, P., Bruneau, A., Wiele, T., van der, Willy Verstraete, Zoetendal, E.G., El Aidy, Sahar, Gerard, Philippe, Abbeele, P., van den, Muriel Derrien, Smidt, Hauke, Van de Wiele, Tom, Gérard, P., Van den Abbeele, Pieter, Bruneau, Aurelia, El Aidy, S.F., Aurélia Bruneau   +44 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Advanced Science, 2021
Increasing evidence has suggested that chemotherapeutics affect the integrity of the intestinal barrier and alter the intestinal microbiota, thus limiting the therapeutic outcomes of cancer chemotherapy.
Qingya Liu, Yi Lu, Yao Xiao, Liping Yuan, Danrong Hu, Ying Hao, Ruxia Han, Jinrong Peng, Zhiyong Qian   +8 more
doaj   +1 more source

Microbiota intestinal y cáncer

Revista de Nutrición Clínica y Metabolismo, 2021
La microbiota es el conjunto de microorganismos localizado en diferentes sitios del cuerpo. Aquellos que se encuentran en el intestino tienen un rol esencial, debido a la estrecha relación que tienen con la salud y la enfermedad, en especial el cáncer. Conocer qué microorganismos pueblan el tracto gastrointestinal y sus funciones, qué ocurre cuando se ...
Evelyn Paola Frias-Toral, Dolores Rodriguez-Veintimilla   +1 more
openaire   +3 more sources

Avaliação da microbiota intestinal e sua relação com parâmetros metabólicos em mulheres com obesidade mórbida [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2014Introdução: A microbiota intestinal refere-se aos micro-organismos que reside no trato ...
Beserra, Bruna Teles Soares
core