Results 31 to 40 of about 154,614 (269)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Vitamin E Improves Morphology and Absorptive Surface of Small Intestine in Broiler Chickens Reared at High Altitude [PDF]

Poultry Science Journal, 2016
Under high altitude conditions, the effects of vitamin E (α-tocopherol) on growth performance, intestinal morphology (villus size and type), and absorptive surface area of broiler chickens were evaluated. Chickens were fed diets supplemented with 0, 100,
Hassanpour H, Bahadoran S, Borjian N
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Effects of Chinese Gallotannins on Antioxidant Function, Intestinal Health, and Gut Flora in Broilers Challenged with Escherichia coli Lipopolysaccharide

Animals
This experiment was conducted to study the protective effects of dietary Chinese gallotannins (CGT) supplementation against Escherichia coli lipopolysaccharide (LPS)-induced intestinal injury in broilers.
Yuemeng Fu, Peng Yuan, Nadia Everaert, Luke Comer, Shuzhen Jiang, Ning Jiao, Libo Huang, Xuejun Yuan, Weiren Yang, Yang Li   +9 more
doaj   +1 more source

Development of Intestinal Injury and Restoration of Weaned Piglets under Chronic Immune Stress

Antioxidants, 2022
This study aimed to investigate the effects of lipopolysaccharide (LPS)-induced chronic immune stress on intestinal morphology and function, immune system, oxidative status, and mitochondrial function in piglets.
Jiayi Yu, Changbing Zheng, Jie Zheng, Geyan Duan, Qiuping Guo, Peiwen Zhang, Mengliao Wan, Yehui Duan   +7 more
doaj   +1 more source

Morphological features and microbiota of the small intestine

Journal of Siberian Medical Sciences, 2023
a single organ, without a clear division into segments. The problem of intestinal anastomotic leakage has not yet been resolved, and its proportion is from 3.4 to 15.3%, with a mortality rate of up to 18.6%. Identification of the anatomical features of different segments of the small intestine and their contents is of practical importance in surgery ...
А.V. Kuznetsov, О.V. Sorokin, L.Yu. Kostina, M.A. Karpov, А.P. Nadeev, V.V. Dolgov, А.А. Glazkov   +6 more
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring the underlying mechanisms behind poor faecal integrity in yellowtail kingfish (Seriola lalandi): The role of dietary starch level and amylase supplementation

Aquaculture Reports
This study explored potential underlying mechanisms (e.g. chyme characteristics, fermentation, and intestinal morphology), that contribute to the negative effect of high dietary starch on faecal integrity in yellowtail kingfish (Seriola lalandi ...
Peter Horstmann Zuther, Roel M. Maas, Tijmen Blok, Jeroen Kals, Marit A.J. Nederlof, Satya Prakash, Henk A. Schols, Thomas W.O. Staessen, Yaqing Zhang, Fotini Kokou, Johan W. Schrama   +10 more
doaj   +1 more source