Results 41 to 50 of about 154,954 (267)

Exploring the underlying mechanisms behind poor faecal integrity in yellowtail kingfish (Seriola lalandi): The role of dietary starch level and amylase supplementation

Aquaculture Reports
This study explored potential underlying mechanisms (e.g. chyme characteristics, fermentation, and intestinal morphology), that contribute to the negative effect of high dietary starch on faecal integrity in yellowtail kingfish (Seriola lalandi ...
Peter Horstmann Zuther, Roel M. Maas, Tijmen Blok, Jeroen Kals, Marit A.J. Nederlof, Satya Prakash, Henk A. Schols, Thomas W.O. Staessen, Yaqing Zhang, Fotini Kokou, Johan W. Schrama   +10 more
doaj   +1 more source

MULTIPHOTON MICROSCOPIC IMAGING OF MOUSE INTESTINAL MUCOSA BASED ON TWO-PHOTON EXCITED FLUORESCENCE AND SECOND HARMONIC GENERATION [PDF]

Journal of Innovative Optical Health Sciences, 2013
Multiphoton microscopy (MPM), based on two-photon excited fluorescence and second harmonic generation, enables direct noninvasive visualization of tissue architecture and cell morphology in live tissues without the administration of exogenous contrast ...
REN'AN XU, XIAOQIN ZHU, NING HE, SHUANGMU ZHUO, JIAN XU, SHANGHAI JIANG, HONGSHENG LI, JIANXIN CHEN   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Combined supplementation with isochlorogenic acid and quercetagetin ameliorates dexamethasone-induced intestinal injury via attenuation of oxidative stress and inflammation

Frontiers in Veterinary Science
Oxidative stress is a critical factor impairing intestinal function and homeostasis in broilers, particularly under dexamethasone (DEX)-induced conditions.
Xiaoning Li, Yilin Feng, Songkang Bai, Pengyu Zhao, Ruihui Dai, Ning Li   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Nature Communications, 2016
The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury,
Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficiency of Fresh and Fermented Banana Stem in Low Protein Diet on Nutrient Digestibility, Productive Performance and Intestinal Morphology of Crossbred Pig ((Thai native x Meishan) x Duroc)

Veterinary Integrative Sciences, 2020
Banana stem is a common feed component for raising pigs in mountainous Southeast Asia. However, its nutritive value and digestibility are low. This study was carried out to investigate the effects of unfermented and fermented banana stems on ...
Chaiwat Arjin, Chanmany Souphannavong, Apinya Sartsook, Mintra Seel-audom, Supamit Mekchay, Korawan Sringarm   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source