Results 81 to 90 of about 190,688 (308)

A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]

, 2015
Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core   +1 more source

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]

, 2016
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson, Anisimov, Atarashi, Augustine, Bates, Blackwell, Chen, Dai, de Oliveira, Ericsson, Ericsson, Flynn, Goldman, Halloran, Hard, Harrison, Hothorn, Johnson, Johnson, Johnson, Kaeberlein, Lamming, Majumder, Mannick, Mathew, Miller, Miller, Paulson, Prakash, Ramos, Treuting, Wilkinson, Xu, Zhang   +33 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Diagnostic Performance of Magnifying Endoscopy With Crystal Violet Staining for Superficial Non‐ampullary Duodenal Epithelial Tumors: A Single‐center Prospective Study

DEN Open
Objectives We previously reported a potential diagnostic algorithm for superficial non‐ampullary duodenal epithelial tumors (SNADETs) using white‐light magnifying endoscopy with crystal violet staining (ME‐CV).
Tomo Kumei, Yosuke Toya, Shun Yamada, Makoto Eizuka, Shunichi Yanai, Masaki Endo, Ryo Sugimoto, Noriyuki Uesugi, Tamotsu Sugai, Naoki Yanagawa, Fumiaki Takahashi, Takayuki Matsumoto   +11 more
doaj   +1 more source

Cadaveric renal transplantation under cyclosporine-steroid therapy [PDF]

, 1983
Ninety-seven cadaveric renal transplants were performed upon 96 patients during 1981. The one year patient mortality was 2.1 per cent. Seventy of the recipients were undergoing trasplantation for the first time.
Hakala, TR, Iwatsuki, S, Rosenthal, JT, Shaw, BW, Starzl, TE   +4 more
core  

Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall [PDF]

, 2018
Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes.
AGOSTINELLI, CLAUDIO, Bertuzzi, Clara, BRIGNOLA, STEFANO, Pillon, Marta, Pizzi, Marco, Righi, Simona, Rugge, Massimo, Sabattini, Elena, Semenzato, Gianpietro   +8 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Diagnostic imaging and CEUS findings in a rare case of Desmoid-type fibromatosis. A case report [PDF]

, 2018
Desmoid-type fibromatosis (DF), also known as aggressive fibromatosis, is a locally aggressive benign fibroblastic neoplasm that can infiltrate or recur but cannot metastasize.
De Felice, Carlo, De Soccio, Valeria, Drudi, Francesco Maria, Liberatore, Mauro, Maghella, Fabrizio, Messineo, Daniela, Valentino, Massimo   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias [PDF]

, 2001
Background: The adenoma-carcinoma sequence has its molecular basis in several gene mutations of which K-ras and p53 are of paramount importance. The aims of this study were to evaluate whether these genetic alterations can be detected in colonic lavage ...
Folwaczny, Christian, Heinzlmann, M., Heldwein, W., Neynaber, S.   +3 more
core   +1 more source