Results 101 to 110 of about 992,849 (343)

Generation of an induced pluripotent stem cell line (FDCHi008-A) from an infant with chronic intestinal pseudo-obstruction

open access: yesStem Cell Research, 2023
Chronic intestinal pseudo-obstruction (CIPO) is a rare condition characterized by intestinal obstruction without any restriction or occlusion, that represents the most severe form of gastrointestinal dysmotility.
Haoyan Liang   +3 more
doaj  

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

open access: yesMolecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

A Rare Case of Intestinal Tuberculosis with Chronic Partial Small Bowel Obstruction in a 37-Year-Old Ethiopian Man

open access: yesInternational Medical Case Reports Journal, 2022
Alazar Berhe Aregawi,1 Alemwosen Teklehaimanot Alem,2 Abdulkerim Girma3 1Department of Surgery, Hawassa University Comprehensive Specialized Hospital, Hawassa University, Hawassa, Sidama, Ethiopia; 2Department of Pathology, Hawassa University ...
Aregawi AB, Alem AT, Girma A
doaj  

The Advantages of Minimally Invasive Surgery for Peritoneal Adhesions in Children

open access: yesПедиатрическая фармакология, 2018
Background. Laparoscopic surgery has advantages over laparotomy. In pediatric practice, only single studies have been devoted to the leading role of laparoscopy in the treatment of peritoneal adhesions in children; randomized controlled studies have not ...
Elena Yu. Dyakonova   +3 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Intestinal obstruction: Role of multi-slice CT in emergency department

open access: yesAlexandria Journal of Medicine, 2014
Objective: This article presents the characteristic CT imaging findings for different causes of intestinal obstruction, in correlation with their clinical background in emergency department.
Khaled Aly Matrawy, Mohamed El-Shazly
doaj   +1 more source

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