Results 81 to 90 of about 668,258 (255)

An interesting case of faecolith intestinal obstruction

, 2017
Intestinal obstruction is a common presentation in surgical wards. Faecolith causing intestinal obstruction are of rare occurrence that too in small bowel. We are herewith presenting a case of intestinal obstruction in small bowel due to Faecolith.
Vivek Kumar Joshi, Sujan Narayan Agrawal, Vineet Mittal   +2 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Management with Conservative Gastrointestinal Decompression and Intravenous Immunoglobulin Relieved Intestinal Obstruction in Kawasaki Disease: A Case Report

Journal of Clinical Question
Background: Kawasaki disease (KD) is an acute febrile vasculitis that predominantly affects children under 5 years of age. Although gastrointestinal symptoms are common, severe complications, such as intestinal obstruction, are rare but clinically ...
Yuta Baba, Yumeng Zhang, Yuri Ishida, Akira Iwanaga, Aiko Kumamoto, Takeshi Yamanouchi, Shinji Nishimura   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Acute Neonatal Intestinal Obstruction

, 1958
The newborn infant ejected from his comfortable isothermic habitat into a hostile world has many physiological adjustments to make in the first four weeks of life.
Charles Marks (8044088)
core   +1 more source

Internal hernia: isolated small intestinal peritoneal encapsulation, a rare cause of acute intestinal obstruction in adolescent: a case report [PDF]

, 2019
Intestinal peritoneal encapsulation as the sole cause of acute intestinal obstruction in adolescent is rare. It poses a diagnostic dilemma where there is lack of high technological equipment to aid diagnosis, usually confirmed at surgery.
Mbaeri, T.U., Abiahu, J.A.
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A Rare Case of Intestinal Obstruction due to Taenia Saginata [PDF]

: Intestinal obstruction may be duo to various mechanical or functional reasons. Worms, especially Ascaris worms are one of the mechanical reasons of intestinal obstruction. Obstruction due to Taenia saginata is a rare phenomenon. Here we report a case
Lashkarizadeh MR, Poor Seyedi B, Samare Fekri M, Aghaee Afshar M,
core