Angewandte Chemie, EarlyView.An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang +5 more
wiley +2 more sources
Systemic Sclerosis-Related Intestinal Pseudo-Obstruction Mimicking Mechanical Small Bowel Obstruction. [PDF]
CureusFareed A, Petit J.
europepmc +1 more source
Accelerating Materials Discovery: A Review of Machine Learning in X‐Ray Absorption Spectroscopy
Advanced Intelligent Systems, EarlyView.This review systematically details how machine learning transforms X‐ray absorption spectroscopy (XAS) analysis. It covers advanced deep learning architectures for structure‐spectra mapping and inverse tasks, while discussing key challenges like the simulation‐to‐reality gap.
Melaku Lake Tegegne +5 more
wiley +1 more source
Post‐Synthetic Zinc Modifications to Correct Speciation in Ti‐MWW Zeolites for Catalytic Oxidation
Angewandte Chemie, EarlyView.Post‐synthetic Zn modifications of Ti‐MWW zeolite catalysts exhibit improved catalytic properties in the selective oxidation reaction, namely the ammoximation reaction. The origin of the beneficial effect of Zn is related via an array of spectroscopic and microscopic techniques to the modification of extra‐framework TiO2 and TiOx clusters and the ...
Christoph J. Kaul +10 more
wiley +2 more sources
American Journal of Agricultural Economics, EarlyView.Abstract Preferential trade agreements (PTAs) contain various non‐tariff provisions, yet identifying their trade effects remains challenging because these commitments are high‐dimensional and strongly correlated within agreements. We estimated a theory‐consistent structural gravity model with domestic flows for 26 agricultural subsectors over 1988–2017
Dongin Kim, Sandro Steinbach
wiley +1 more source
Potential role of pyridostigmine in the management of pediatric chronic intestinal pseudo-obstruction in a girl with ACTL6B mutation: a case report and a review of literature. [PDF]
Front PediatrRulli I +7 more
europepmc +1 more source
The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle +3 more
wiley +1 more source
Palladium‐Catalyzed Annulations of an Anti‐Bredt Olefin
Angewandte Chemie, EarlyView.We report metal‐catalyzed trappings of a [2.2.1]‐bridged bicyclic anti‐Bredt olefin (ABO). The methodology yields unusual heterocyclic products and is expected to prompt the further development of unconventional reactions, including metal‐catalyzed processes of ABOs and other strained olefins. ABSTRACT A famous class of alkene‐containing compounds that
Zach G. Walters +3 more
wiley +2 more sources
Nutrition Support for Children with Paediatric Intestinal Pseudo-Obstruction (PIPO) in the United Kingdom-An Explorative Survey by the British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN). [PDF]
NutrientsMari A +4 more
europepmc +1 more source
C─S Bond Formation of Aryl Germanes
Angewandte Chemie, EarlyView.Site‐selective C─S bond formation of aryl germanes, even in the presences of other functional groups such as silane or boron derivatives, is described. The protocol operates under metal‐free conditions at room temperature without the need of inert atmosphere.
Jaime Ponce‐de‐León +6 more
wiley +2 more sources