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Intestinal stem cells and intestinal organoids
Journal of Genetics and Genomics, 2020The intestinal epithelium is one of the most rapidly renewing tissues, which is fueled by stem cells at the base of the crypts. Strategies of genetic lineage tracing and organoids, which capture major features of original tissues, are powerful avenues for exploring the biology of intestinal stem cells in vivo and in vitro, respectively. The combination
Qian, Zhao, Jiawei, Guan, Xia, Wang
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Journal of Pediatric Gastroenterology and Nutrition, 2009
ABSTRACTThe epithelial cell lining of the gastrointestinal tract is the most rapidly proliferating tissue in the body. The constant state of renewal of differentiated epithelial cells is sustained by a continual supply of progeny from multipotent progenitors that originate from stem cells located within the intestinal crypts.
Aaron P, Garrison +2 more
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ABSTRACTThe epithelial cell lining of the gastrointestinal tract is the most rapidly proliferating tissue in the body. The constant state of renewal of differentiated epithelial cells is sustained by a continual supply of progeny from multipotent progenitors that originate from stem cells located within the intestinal crypts.
Aaron P, Garrison +2 more
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Current Opinion in Gastroenterology, 2013
To summarize our current understanding of small intestinal stem cell biology and the current tools available for studying intestinal stem cells (ISCs).Recent reviews and original reports point toward the presence of two distinct populations of stem cells (ISCs) within the intestinal crypts.
Stephanie L, King +1 more
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To summarize our current understanding of small intestinal stem cell biology and the current tools available for studying intestinal stem cells (ISCs).Recent reviews and original reports point toward the presence of two distinct populations of stem cells (ISCs) within the intestinal crypts.
Stephanie L, King +1 more
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Intestinal stem cell transplantation
Journal of Gastroenterology, 2016Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article,
Tetsuya, Nakamura, Mamoru, Watanabe
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Gastrointestinal Stem Cells. II. Intestinal stem cells
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein ...
Matthew, Bjerknes, Hazel, Cheng
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The intestinal epithelial stem cell
BioEssays, 2002AbstractThis article considers the role of the adult epithelial stem cell, with particular reference to the intestinal epithelial stem cell. Although the potential of adult stem cells has been revealed in a number of recent publications, the organization and control of the stem cell hierarchy in epithelial tissues is still not fully understood.
Emma, Marshman +2 more
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Bioelectric regulation of intestinal stem cells
Trends in Cell Biology, 2023Proper regulation of ion balance across the intestinal epithelium is essential for physiological functions, while ion imbalance causes intestinal disorders with dire health consequences. Ion channels, pumps, and exchangers are vital for regulating ion movements (i.e., bioelectric currents) that control epithelial absorption and secretion.
Afroditi, Petsakou, Norbert, Perrimon
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LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis
Nature Cell Biology, 2018The intestinal epithelium harbours remarkable self-renewal capacity that is driven by Lgr5+ intestinal stem cells (ISCs) at the crypt base. However, the molecular mechanism controlling Lgr5+ ISC stemness is incompletely understood. We show that a Gata6 long noncoding RNA (lncGata6) is highly expressed in ISCs.
Pingping Zhu +20 more
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Intestinal stem cells and inflammation
Current Opinion in Pharmacology, 2015The intestinal epithelium is renewed every 3-5 days from at least two principal stem cell pools. Actively cycling crypt based columnar (CBC) Lgr5(+) cells and slower cycling Bmi1-expressing or Krt19-expressing cells maintain the small intestinal and colonic epithelium in homeostasis and injury.
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