Results 271 to 280 of about 128,505 (309)

Bioelectric regulation of intestinal stem cells

Trends in Cell Biology, 2023
Proper regulation of ion balance across the intestinal epithelium is essential for physiological functions, while ion imbalance causes intestinal disorders with dire health consequences. Ion channels, pumps, and exchangers are vital for regulating ion movements (i.e., bioelectric currents) that control epithelial absorption and secretion.
Afroditi, Petsakou, Norbert, Perrimon
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The intestinal epithelial stem cell

BioEssays, 2002
AbstractThis article considers the role of the adult epithelial stem cell, with particular reference to the intestinal epithelial stem cell. Although the potential of adult stem cells has been revealed in a number of recent publications, the organization and control of the stem cell hierarchy in epithelial tissues is still not fully understood.
Emma, Marshman, Catherine, Booth, Christopher S, Potten   +2 more
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Gastrointestinal Stem Cells. II. Intestinal stem cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein ...
Matthew, Bjerknes, Hazel, Cheng
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Stem Cells and Inflammation in the Intestine

2011
Knowledge of stem cell biology in the intestine is increasing exponentially and it is one of the current hot topics 'of the day'. Yet it is only recently that molecules such as Lgr5 and Bmi1 have been shown to reliably mark stem cells and have revealed the stem cell location throughout the murine gastrointestinal tract.
Adam, Humphries, Trevor A, Graham, Stuart A C, McDonald   +2 more
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Intestinal stem cells and inflammation

Current Opinion in Pharmacology, 2015
The intestinal epithelium is renewed every 3-5 days from at least two principal stem cell pools. Actively cycling crypt based columnar (CBC) Lgr5(+) cells and slower cycling Bmi1-expressing or Krt19-expressing cells maintain the small intestinal and colonic epithelium in homeostasis and injury.
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LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis

Nature Cell Biology, 2018
The intestinal epithelium harbours remarkable self-renewal capacity that is driven by Lgr5+ intestinal stem cells (ISCs) at the crypt base. However, the molecular mechanism controlling Lgr5+ ISC stemness is incompletely understood. We show that a Gata6 long noncoding RNA (lncGata6) is highly expressed in ISCs.
Pingping Zhu, Jiayi Wu, Yanying Wang, Xiaoxiao Zhu, Tiankun Lu, Benyu Liu, Luyun He, Buqing Ye, Shuo Wang, Shu Meng, Dongdong Fan, Jing Wang, Liuliu Yang, Xiwen Qin, Ying Du, Chong Li, Lei He, Weizheng Ren, Xin Wu, Yong Tian, Zusen Fan   +20 more
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Nutritional Regulation of Intestinal Stem Cells

Annual Review of Nutrition, 2018
Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases ...
Salvador, Alonso, Ömer H, Yilmaz
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Autophagy Detection in Intestinal Stem Cells

2020
Autophagy is a lysosomal degradation pathway with important roles in physiological homeostasis and disease. We previously showed that intrinsic autophagy in intestinal stem cells (ISCs) is important for ISC homeostasis. Here we describe the detailed methods for detecting autophagy in ISCs by observing autophagosomes in GFP-LC3 transgenic mice and ...
Jumpei, Asano, Taku, Sato, Toshiaki, Ohteki   +2 more
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Epithelial stem cells and intestinal cancer

Seminars in Cancer Biology, 2015
The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration.
Shawna, Tan, Nick, Barker
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Stem cells of small intestinal epithelium

Bulletin of Experimental Biology and Medicine, 2008
Intestinal epithelium is a rapidly proliferating tissue and represents a unique model for the study of somatic stem cells. Here we summarized the data about markers, main properties, and methods of isolation of intestinal epithelial cells. Some aspects of molecular biology of the intestine are also discussed.
L A, Vedina, S V, Sennikov, V A, Trufakin, V A, Kozlov   +3 more
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