1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells In Vitro and In Vivo. [PDF]
Shaikh NA +4 more
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Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development. [PDF]
Ho J +5 more
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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells. [PDF]
Li Y +12 more
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<i>Bacillus amyloliquefaciens</i> SC06 Ameliorated Intestinal Mucosal Injury by Regulated Intestinal Stem Cells Proliferation and Differentiation via Activating Wnt/β-Catenin Signal Pathway in <i>Clostridium perfringens</i>-Challenged Mouse. [PDF]
Deng H +6 more
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Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway. [PDF]
Wang S, Liu X, Xu L, Lang J, Liu D.
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Intestinal stem cells and intestinal organoids
Journal of Genetics and Genomics, 2020The intestinal epithelium is one of the most rapidly renewing tissues, which is fueled by stem cells at the base of the crypts. Strategies of genetic lineage tracing and organoids, which capture major features of original tissues, are powerful avenues for exploring the biology of intestinal stem cells in vivo and in vitro, respectively. The combination
Qian, Zhao, Jiawei, Guan, Xia, Wang
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ABSTRACTThe epithelial cell lining of the gastrointestinal tract is the most rapidly proliferating tissue in the body. The constant state of renewal of differentiated epithelial cells is sustained by a continual supply of progeny from multipotent progenitors that originate from stem cells located within the intestinal crypts.
Aaron P, Garrison +2 more
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To summarize our current understanding of small intestinal stem cell biology and the current tools available for studying intestinal stem cells (ISCs).Recent reviews and original reports point toward the presence of two distinct populations of stem cells (ISCs) within the intestinal crypts.
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Intestinal stem cell transplantation
Journal of Gastroenterology, 2016Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article,
Tetsuya, Nakamura, Mamoru, Watanabe
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