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Epithelial stem cells and intestinal cancer
Seminars in Cancer Biology, 2015The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration.
Shawna, Tan, Nick, Barker
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Nutritional Regulation of Intestinal Stem Cells
Annual Review of Nutrition, 2018Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases ...
Salvador, Alonso, Ömer H, Yilmaz
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Autophagy Detection in Intestinal Stem Cells
2020Autophagy is a lysosomal degradation pathway with important roles in physiological homeostasis and disease. We previously showed that intrinsic autophagy in intestinal stem cells (ISCs) is important for ISC homeostasis. Here we describe the detailed methods for detecting autophagy in ISCs by observing autophagosomes in GFP-LC3 transgenic mice and ...
Jumpei, Asano +2 more
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2013
Gastro intestinal epithelium (GI) is a rapidly proliferating tissue and is a suitable model for study of stem cell biology. GI stem cells are mainly identified as esophageal, gastric, intestinal, hepatic and pancreatic stem cells. Intestinal stem cells are most extensively studied in mouse models. In the small intestine stem cells reside at the base of
M. Sasikala +3 more
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Gastro intestinal epithelium (GI) is a rapidly proliferating tissue and is a suitable model for study of stem cell biology. GI stem cells are mainly identified as esophageal, gastric, intestinal, hepatic and pancreatic stem cells. Intestinal stem cells are most extensively studied in mouse models. In the small intestine stem cells reside at the base of
M. Sasikala +3 more
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Protecting intestinal stem cells
Science, 2019Mucosal Immunology The intestinal epithelium is replaced every week. Thus, maintenance of this tissue requires rapid self-renewal driven by intestinal stem cells. This homeostasis is disrupted in a number of settings, including allogeneic bone marrow transplantation. After bone marrow transplantation, allogeneic T cells often attack and kill intestinal
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2010
The intestinal epithelium is one of the most rapidly renewing tissues in the human organism.
Tobias Sperka, Karl Lenhard Rudolph
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The intestinal epithelium is one of the most rapidly renewing tissues in the human organism.
Tobias Sperka, Karl Lenhard Rudolph
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Regulation of intestinal cancer stem cells
Cancer Letters, 2013Colorectal tumours harbour a sub-population of cells with stem like properties termed 'cancer stem cells', which are believed to ultimately drive cancer growth. This review discusses recent advances in our understanding of both normal and cancer intestinal stem cells, with emphasis on similarities and differences.
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Onconephrology: The intersections between the kidney and cancer
Ca-A Cancer Journal for Clinicians, 2021, Kenar D Jhaveri, Mark A Perazella
exaly
[Stem Cell System. The intestinal stem cell system.]
Clinical calcium, 2017The intestinal epithelium harbors stem cells at the bottom of crypts. Intestinal stem cells(ISCs)differentiate toward two alternative lineages of secretory or absorptive cells in a unidirectional manner. Studies have revealed factors that are indispensable for maintaining proliferation and differentiation of ISCs, which are provided from the ...
Fumiaki, Ishibashi +2 more
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