Results 71 to 80 of about 844,508 (249)

Immunosuppression-free Nonvascularized Rectus Fascia Allotransplantation for Complex Hernia Repair

Transplantation Direct
Background. Complex abdominal wall herniations present major reconstructive challenges, particularly in patients with contaminated fields or previous failed repairs.
Laurens J. Ceulemans, MD, PhD, Ewout Muylle, MD, Gert De Hertogh, MD, PhD, Cedric Vanluyten, MD, Antoine Dubois, MD, Jan Van Slambrouck, MD, PhD, Caroline Boelhouwer, MD, Marina Gabriela M. C. Mori da Cunha, PhD, Ina Hennion, MSc, Antoine Weisrock, MSc, Lieven Thorrez, PhD, Ina Benoy, PhD, Steffi De Pelsmaeker, PhD, Angelica Pagliazzi, MD, Maarten Naesens, MD, PhD, Nathalie P. Deferm, MD, Albert Wolthuis, MD, PhD, André D´Hoore, MD, PhD, Jacques Pirenne, MD, PhD, Nele Van De Winkel, MD, PhD   +19 more
doaj   +1 more source

Intestinal Obstruction Due to Internal Hernia Following Pancreas Transplantation

, 2010
Background. Simultaneous pancreas-kidney transplantation has evolved as the best treatment for type 1 diabetic patients at end-stage renal disease. the surgical complication rate is high, which is an important barrier to the success of this procedure ...
Matos, D. [UNIFESP], Sa, J. R. [UNIFESP], Melaragno, C. [UNIFESP], Rangel, E. [UNIFESP], del Grande, L. [UNIFESP], Medina Pestana, J. O. [UNIFESP], Salzedas, A. [UNIFESP], Vicentine, F. P. [UNIFESP], Lopes-Filho, G. J. [UNIFESP], Sousa, Marcelo Goncalves [UNIFESP], Linhares, M. M. [UNIFESP], Gonzalez, A. [UNIFESP]   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry

, 2008
Background: Intestinal transplantation is a potential treatment for patients with irreversible intestinal failure. However, the long-term outcome is still unsatisfactory compared with transplantation of other solid organs because of transplantation ...
Li, Ning, Zhang, Qiang, Yin, Peiyuan, Li, Qiurong, Li, Jieshou, 黎介寿, Xu, Guowang   +6 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Long-term Outcomes after Intestinal and Multi-visceral Transplantation

, 2014
Intestinal transplantation is a life‐saving procedure for patients with complicated intestinal failure. Its potential for sustained success is manifest by several patients alive more than 20 years after transplantation who are nutritionally independent ...
Andreas Tzakis, Tekin, Akin, Ruiz, Phillip, Selvaggi, Gennaro, Phillip Ruiz, Akin Tekin, Garcia, Jennifer, Jennifer Garcia, Gennaro Selvaggi, Tzakis, Andreas   +9 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Graft-versus-host Disease After Intestinal or Multivisceral Transplantation: A Scandinavian Single-center Experience

, 2016
Graft-versus-host disease (GVHD) that develops after intestinal or multivisceral transplantation is difficult to diagnose and is associated with high morbidity and ...
Varkey, Jonas,, Wennerås, Christine,, Herlenius, Gustaf,, Johansson, Jan-Erik,, Cromvik, Julia,   +4 more
core   +1 more source

The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis [PDF]

, 2019
Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need.
Van Haaften, W T, Spalinger, M R, Raselli, T., Sailer, A. W., Alvarado, M. N. Gonzalez, Rogler, G., Silva, P. H. Imenez, Hausmann, M, van Haaften, W. T., Weder, B, Tosevski, V., Scharl, M., Misselwitz, B., Misselwitz, B, Imenez Silva, P H, Scharl, M, Wagner, C A, Wyss, A., Dijkstra, G., Hausmann, M., Sailer, A W, Raselli, T, Wyss, A, Dijkstra, G.; id_orcid, Gonzalez Alvarado, M N, Mamie, C., Spalinger, M. R., Leibl, Sebastian, Wagner, C. A., Tosevski, V, Mamie, C, Dijkstra, G, Rogler, G, Weder, B.   +33 more
core   +2 more sources