Results 191 to 200 of about 689,502 (309)

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

open access: yesAdvanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis   +7 more
wiley   +1 more source

<i>Akkermansia muciniphila</i> Selectively Reshapes Small Intestinal Cell Populations. [PDF]

open access: yesJ Histochem Cytochem
Edens-Valentine R   +3 more
europepmc   +1 more source

Durability of Soft Pneumatic Actuators: A Review and Benchmarking Protocol

open access: yesAdvanced Robotics Research, EarlyView.
Lack of durability is a key challenge hindering the broad scale adoption of soft pneumatic actuators (SPAs) in automation industries. This review provides a comprehensive overview of existing research on SPA durability, introduces a standardized durability benchmarking protocol to consolidate the testing of SPAs, and outlines promising directions for ...
Dickson Chiu Yu Wong   +2 more
wiley   +1 more source

Hybrid Continuum Robot Designs and Architectures for Healthcare Applications

open access: yesAdvanced Robotics Research, EarlyView.
Hybrid continuum robots represent an emerging class of flexible manipulators that blend materials, structures, and actuation concepts from the established fields of soft and continuum robotics. This review introduces an accessible framework to distinguish key hybridization approaches, surveys current designs aimed at complex clinical applications, and ...
Burak Ozdemir   +4 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

open access: yesAdvanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang   +10 more
wiley   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang   +18 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

open access: yesAdvanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao   +16 more
wiley   +1 more source

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