Results 71 to 80 of about 552,709 (414)
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.
Annual Review of Pathology, 2013 The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic immune-mediated diseases. Particularly in tissues that interface with the microbial environment-such as
C. Weaver, C. Elson, L. Fouser, J. Kolls
semanticscholar +1 more source
CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]
, 2019 Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank +14 more
core +1 more source
Intestinal Macrophages and Intestinal Infection
Biosciences Biotechnology Research Asia, 2021 There has been increased interest in the role played by macrophages in the maintenance of an active immune system and intestinal homeostasis. Nonetheless, they are also responsible for the rise of chronic pathologies such as inflammatory bowel syndrome in the gut.
Hadba Al-Amrah +4 more
openaire +2 more sources
Electronic Physician, 2015 Introduction: Cyclophosphamide (CP) is alkylating agent and the most commonly used chemotherapeutic drug for various types of cancer; it causes severe toxicity.
Salwa Mohammed Quita +1 more
doaj +1 more source
Tipping Elements in the Human Intestinal Ecosystem [PDF]
, 2014 Recent studies show that the microbial communities inhabiting the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults we identified groups of ...
arxiv +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Absorbed radiation dosimetry of the D3-specific PET radioligand [18F]FluorTriopride estimated using rodent and nonhuman primate [PDF]
, 2016 [(18)F]FluorTriopride ([(18)F]FTP) is a dopamine D(3)-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosimetry for [(
Bognar, Christopher +9 more
core +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
PLoS ONE, 2014 Background Gastrointestinal (GI) inflammation in mice and men are frequently accompanied by distinct changes of the GI microbiota composition at sites of inflammation.
M. Heimesaat +7 more
semanticscholar +1 more source