Results 91 to 100 of about 287,112 (303)

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

open access: yesAdvanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao   +10 more
wiley   +1 more source

Statin Intolerance

open access: yesReviews in Cardiovascular Medicine, 2018
Statins are critical medications to prevent and treat cardiovascular disease2 and they are generally very well tolerated. In some instances, however, statin intolerance may limit use of these lifesaving medications. Statin intolerance has many definitions but is commonly diagnosed when a patient is unable to continue statin therapy due to perceived, or
Alan S, Brown, Karol E, Watson
openaire   +2 more sources

Glucose Intolerance on Phaeochromocytoma and Paraganglioma—The Current Understanding and Clinical Perspectives

open access: yes, 2020
Half of the patients with phaeochromocytoma have glucose intolerance which could be life-threatening as well as causing postoperative hypoglycemia. Glucose intolerance is due to impaired insulin secretion and/or increased insulin resistance.
Lam, Alfred King-Yin   +2 more
core   +1 more source

Intolerancia a las estatinas, un reto en la práctica clínica Intolerance to statins: a challenge in clinical practice

open access: yesRevista Colombiana de Cardiología, 2008
Las estatinas son medicamentos hipolipemiantes que han demostrado ser indispensables y seguros en el manejo de la dislipidemia y como prevención secundaria en pacientes de alto riesgo cardiovascular. Sin embargo, en ocasiones su uso se ve limitado por el
Adriana L Vanegas, Nicolás Jaramillo
doaj  

Information Literacy For The Net Generation To Anticipate The Danger Of Intolerance

open access: yesJurnal Aspikom, 2019
Intolerance behaviors that are not anticipated may give birth to the danger of radicalism both psychologically and physically.  This study aims at exploring the way to select and discover informational sources related to the topics; at investigating a ...
Heni Nuraeni Zaenudin, Suwatno .
doaj   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

open access: yesAdvanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen   +12 more
wiley   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

open access: yesAdvanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong   +11 more
wiley   +1 more source

Re-Membering the Past: Historical Film and the Embodied Viewer

open access: yesResearch in Film and History, 2018
In 1895 the Edison short, THE EXECUTION OF MARY, QUEEN OF SCOTS (USA 1895) staged a fully “fleshed out” historical beheading on film. By putting members and flesh onto otherwise mental images of historical figures, the film showcased the new medium’s ...
Allred, Mason Kamana
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

open access: yesAdvanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia   +13 more
wiley   +1 more source

THE INTERRELATION OF INTOLERANT BEHAVIOUR AND NOT ADAPTIVE COPING STRATEGIES IN INTERETHNIC INTERACTION OF THE ELDER TEENAGERS

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2015
The article presents the results of theoretical and empirical research on the interrelation of coping strategies and ethnic tolerance of the elder teenagers.
Marina Sergeevna Igonina
doaj   +1 more source

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