Results 91 to 100 of about 596,709 (351)

Unpacking uncivil society

open access: yesNordicom Review, 2021
In the era of rising populist sentiment, deep social and political polarisations, and a growing crisis of online harms, numerous scholars share concern about the impact of such uncivil populist forces on the health of liberal democracy.
Oh Dayei   +3 more
doaj   +1 more source

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

open access: yes, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E.   +3 more
core   +1 more source

Self-guided mindfulness and cognitive behavioural practices reduce anxiety in autistic adults: A pilot 8-month waitlist-controlled trial of widely available online tools [PDF]

open access: yes, 2020
Anxiety in autism is an important treatment target because of its consequences for quality of life and wellbeing. Growing evidence suggests that Cognitive Behaviour Therapies (CBT) and Mindfulness-Based Therapies (MBT) can ameliorate anxiety in autism ...
Bowler, Dermot M   +19 more
core   +4 more sources

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

open access: yesAdvanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng   +8 more
wiley   +1 more source

Beyond Disability Stigma: Examining Tolerance and Intolerance toward Disability Issues

open access: yesScandinavian Journal of Disability Research
Disability research has focused a lot on stigma but very little on situations where individuals express tolerance or intolerance toward disability issues.
Mark T. Carew, Tom Shakespeare
doaj   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

open access: yesAdvanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang   +8 more
wiley   +1 more source

A comparison of Clinical Risk Index for babies (CRIB-II), Score for Neonatal Acute Physiology (SNAP-II) and SNAPPE-II in predicting parenteral nutrition necessity in low birth weight preterm neonates. [PDF]

open access: yes, 2018
Advances in perinatal care have made it possible to improve survival of low birth weight neonates. Clinical risk index for babies (CRIB-II), score for neonatal acute physiology (SNAP-II), and SNAP-perinatal extension-II (SNAPPE-II) have been used as ...
Bellido Estevez, Inmaculada   +7 more
core  

Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study [PDF]

open access: yes, 2015
Objective To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI).
Beer, Stephen F.   +8 more
core   +2 more sources

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

open access: yesAdvanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen   +28 more
wiley   +1 more source

Disaccharide intolerance

open access: yesSrpski arhiv za celokupno lekarstvo, 2010
Disaccharide intolerance presents a pathogenic heterogeneous and most complex clinical entity. It usually occurs due to primary or secondary deficit of disaccharide activity, and rarely because of disorders of absorption or monomer metabolism.
openaire   +3 more sources

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