Results 61 to 70 of about 1,407,869 (246)
SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu +12 morewiley +1 more sourceIs vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity. [PDF]
, 2014 BACKGROUND: Indians may be particularly vulnerable to cardiometabolic disease, potentially due to higher body fat for a given BMI, or a tendency towards depositing abdominal adiposity.Davey-Smith, George, Gupta, Ruby, Kuper, Hannah, Wells, Jonathan, Krishna, Kankipati Vijay, Davey Smith, George, Krishna, Kankipati Vijay Radha, Kulkarni, Bharati, Prabhakaran, Dorairaj, Taylor, Amy, Ben-Shlomo, Yoav, Kinra, Sanjay, Ebrahim, Shah +12 morecore +1 more sourceAdhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy
Advanced Science, EarlyView.An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen +9 morewiley +1 more sourcePathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction
Journal of Cardiovascular Development and Disease, 2023 Background: Visceral fat produces inflammatory cytokines and may play a major role in heart failure with preserved ejection fraction (HFpEF). However, little data exist regarding how qualitative and quantitative abnormalities of visceral fat would ...Reika Nagata, Masaru Obokata, Miki Matsui, Hiroki Matsui, Yuko Seki, Takamichi Igarashi, Hiroaki Sunaga, Ryo Kawakami, Tomonari Harada, Kazuki Kagami, Hiroshi Saeki, Ken Shirabe, Tatsuya Iso, Hideki Ishii +13 moredoaj +1 more sourceGenome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci [PDF]
, 2013 Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat Burke, Gregory L., Neuhouser, Marian L, Rasmussen-Torvik, Laura J., Heather M. Ochs-Balcom (446520), Spruill, I, Fox, Caroline S., Taylor, H, Jaclyn C. Ellis (446504), Mara Z Vitolins, Reiner, AP, Virginia Howard (446524), McKnight, Barbara, Harris, Tamara B, Zhao, W, Matthew A. Allison (174794), Becker, Diane M, Marguerite R. Irvin (102149), Neuhouser, Marian L., Peyser, Patricia A., Angela F. Britton (446514), Howard, BV, Keri L Monda, Brian E Henderson, Borecki, IB, Struan F. A. Grant (203247), Borecki, Ingrid B., Yanek, LR, Liu, Y, Rasmussen-Torvik, Laura J, Monda, Keri L., Yii-Der Ida Chen, Evadnie Rampersaud (73606), Liu, Ching-Ti, Laura J. Rasmussen-Torvik (174672), Liu, S, Henderson, Brian E, Sara S. Strom (202140), Nalls, Michael A., Alexander P. Reiner (178706), Schreiner, Pamela J, Xiuqing Guo (73591), Grant, SFA, Zhao, Wei, Burke, Gregory L, Broeckel, U, Evans, Michele K., Ochs-Balcom, HM, Ambrosone, Christine B., Griffin, PJ, Tamara B Harris, Jingzhong Ding, Kooperberg, Charles, Charles Kooperberg, Guanjie Chen, Mara Z. Vitolins (446505), Thomas H Mosley, Liu, J, Xue, Luting, Christopher A Haiman, Alan B. Zonderman (178692), Bruce Psaty, Chen, Guanjie, Jeanette S Andrews, Kari E. North (68131), Wojczynski, MK, W. Timothy Garvey (113627), Herman Taylor (446523), Taylor, Kira C., North, Kari E, Ambrosone, CB, Joann E Manson, Paula J. Griffin (446507), Sharon L R Kardia, Rasmussen-Torvik, LJ, Wojczynski, Mary K., Simin Liu, Wei Zhao, Josyf Mychaleckyj (5930), Kurt Lohman, Peyser, PA, Mosley, Thomas H, Borecki, Ingrid B, Rotimi, Charles N, Smith, Megan, Demerath, Ellen W, Nyante, Sarah, Kurt Lohman (110218), Taylor, KC, Robert C. Millikan (202086), Guo, Xiuqing, Schreiner, PJ, Julie R. Palmer (446521), Henderson, BE, Bruce Psaty (113671), Lawrence F Bielak, Talin Haritunians (262584), Lynn Rosenberg, Ruiz-Narvaez, EA, Adebowale Adeyemo, Strom, Sara S., Ulrich Broeckel (446517), Jeanette S. Andrews (174941), JoAnn E. Manson (148234), Tamara B. Harris (110195), Rotimi, CN, Rotter, Jerome I, Mychaleckyj, Josyf, Christine B. Ambrosone (202037), Mychaleckyj, J, Mary Cushman (29639), Millikan, Robert C, Fox, CS, Rosenberg, L, Psaty, B, Yanek, Lisa R, Kardia, Sharon LR, Lohman, K, Palmer, JR, Papanicolaou, George J., Christopher A. Haiman (89922), Marian L Neuhouser, Barbara McKnight, Sale, Michele M, Diane M Becker, Strom, SS, Adeyemo, Adebowale, Sun, Yan V, Kira C Taylor, Sucheston, Lara, Lawrence F. Bielak (446522), Chen, Yii-Der Ida, Kabagambe, Edmond, Sun, Yan V., Griffin, Paula J., Liu, CT, Laura J Rasmussen-Torvik, Millikan, Robert C., Ochs-Balcom, Heather M, Jie Zhou, Millikan, RC, Caroline S Fox, Ordovas, Jose M., Virginia Howard, Henderson, Brian E., Luting Xue (446506), Haritunians, Talin, Ding, Jingzhong, Demerath, EW, Cupples, LA, Keri L. Monda (198707), Kuller, Lewis H., Shriner, D, Karen C Johnson, Ellen W Demerath, Garvey, WT, Andrews, Jeanette S., Sarah Nyante (202098), Curtis Pettaway (446513), Ching-Ti Liu (100170), Mosley, Thomas H., L. Adrienne Cupples (113601), Curtis Pettaway, Nalls, Michael A, Barbara V Howard, Harris, TB, Britton, Angela F, Johnson, KC, Julie R Palmer, Bandera, Elisa V, Jingzhong Ding (165392), Li, Guo, Ellis, Jaclyn C., Thomas H. Mosley (206369), Ruiz-Narvaez, Edward A., Psaty, Bruce, Angela F Britton, Papanicolaou, George J, Palmas, W, Speliotes, EK, Jerome I. Rotter (103729), Yongmei Liu, Lara Sucheston (372218), Becker, Diane M., Patel, Sanjay R., Jie Zhou (28945), Rotimi, Charles N., Ching-Ti Liu, Palmer, Julie R., Sale, MM, Stephen B Kritchevsky, Allison, Matthew A, Papanicolaou, GJ, Patel, Sanjay R, Chen, G, Diane M. Becker (113669), Chen, F, Garvey, W. Timothy, Ordovas, JM, Edmond Kabagambe (446516), Lynn Rosenberg (446510), Ding, J, Paula J Griffin, Alexander P Reiner, Carlson, Christopher S., Spruill, Ida, Manson, JoAnn, Vitolins, Mara Z., North, KE, Palmas, Walter R., Ulrich Broeckel, Evadnie Rampersaud, Rotter, JI, Howard, Barbara V., Megan Smith (446509), Carlson, Christopher S, Becker, DM, Zonderman, Alan B., Andrews, Jeanette S, Daniel Shriner, Charles N. Rotimi (137216), Pamela J. Schreiner (113660), Lohman, Kurt, Schreiner, Pamela J., Allison, Matthew A., Brian E. Henderson (89923), Bielak, Lawrence F, Jiankang Liu, Caroline S. Fox (110474), Broeckel, Ulrich, Zonderman, Alan B, Michele K Evans, Michele M Sale, Karen C. Johnson (215618), Wei Zhao (14321), Mary K. Wojczynski (113569), Patricia A Peyser, Ambrosone, Christine B, Zonderman, AB, Lewis H Kuller, Guanjie Chen (28943), Leslie Lange, Edward A Ruiz-Narvaez, Johnson, Karen C, Speliotes, Elizabeth K, Jiankang Liu (48049), Lange, L, Uma Nayak (446511), Vitolins, MZ, Stephen B. Kritchevsky (110259), Kardia, SLR, Kabagambe, E, Patel, SR, Haiman, Christopher A., Speliotes, Elizabeth K., Nayak, U, Sucheston, L, Simin Liu (11987), North, Kari E., Charles N Rotimi, Irvin, MR, Bandera, EV, Chen, Fang, Robert C Millikan, Michael A. Nalls (113680), Christopher S Carlson, Jose M Ordovas, Elisa V. Bandera (202046), Britton, Angela F., Charles Kooperberg (18693), Kritchevsky, SB, Liu, Jiankang, Edmond Kabagambe, Adeyemo, A, Sarah Nyante, George J Papanicolaou, Edward A. Ruiz-Narvaez (5656075), Bielak, LF, Evans, MK, Uma Nayak, Walter Palmas, McKnight, B, Burke, GL, Lisa R Yanek, Vitolins, Mara Z, Sanjay R. Patel (120915), Ida Spruill, Leslie Lange (178678), Irvin, Marguerite R, Demerath, Ellen W., Kuller, LH, Ellis, JC, Johnson, Karen C., Howard, V, Zhou, Jie, Manson, JoAnn E., Palmas, Walter, Haiman, Christopher A, Li, G, Kardia, Sharon L. R., Ingrid B. Borecki (113678), Manson, JAE, Allison, MA, Mosley, TH, Shriner, Daniel, Bielak, Lawrence F., Chen, Wei-Min, Wei-Min Chen (110472), Grant, Struan F. A., Patricia A. Peyser (446515), McCarthy, Mark I., Harris, Tamara B., Struan F A Grant, Jerome I Rotter, Cupples, L Adrienne, Liu, Simin, Cupples, L. Adrienne, Nayak, Uma, Pamela J Schreiner, Michele K. Evans (27920), Elisa V Bandera, Herman Taylor, Chen, YDI, Marguerite R Irvin, Ida Spruill (446512), Gregory L Burke, Haiman, CA, Carlson, CS, Irvin, Marguerite R., Liu, Yongmei, Fang Chen, Guo Li (174860), Yanek, Lisa R., Kuller, Lewis H, Sylvia Wassertheil-Smoller, Ruiz-Narvaez, Edward A, Fox, Caroline, Lange, Leslie, Palmer, Julie R, Marian L. Neuhouser (446519), Megan Smith, Ellis, Jaclyn C, Rampersaud, E, Ochs-Balcom, Heather M., Ingrid B Borecki, Guo Li, Lewis H. Kuller (301146), Nyante, S, Walter Palmas (171554), W Timothy Garvey, Strom, Sara S, Jaclyn C Ellis, Nalls, MA, Ordovas, Jose M, Sylvia Wassertheil-Smoller (446518), Barbara V. Howard (215615), Elizabeth K Speliotes, Smith, M, Cushman, M, Talin Haritunians, Taylor, Kira C, Heather M Ochs-Balcom, Fang Chen (34476), Elizabeth K. Speliotes (145716), Guo, X, Kooperberg, C, Gregory L. Burke (217200), Grant, Struan FA, Wassertheil-Smoller, S, Kritchevsky, Stephen B, Michael A Nalls, Neuhouser, ML, Monda, Keri L, Yan V Sun, Evans, Michele K, Reiner, Alexander P, Yii-Der Ida Chen (113593), Josyf Mychaleckyj, Sharon L. R. Kardia (175092), Sanjay R Patel, Monda, KL, Lara Sucheston, Alan B Zonderman, Daniel Shriner (137188), Sara S Strom, Xiuqing Guo, Kari E North, Lisa R. Yanek (113564), Zhou, J, Adebowale Adeyemo (28944), Luting Xue, Kritchevsky, Stephen B., Rampersaud, Evadnie, Howard, Barbara V, Cushman, Mary, Taylor, Herman, Wojczynski, Mary K, George J. Papanicolaou (163242), Andrews, JS, Haritunians, T, Jose M. Ordovas (2605621), Xue, L, Barbara McKnight (103714), Christine B Ambrosone, Chen, WM, Mary K Wojczynski, Britton, AF, Rosenberg, Lynn, Griffin, Paula J, Sun, YV, Yan V. Sun (446508), Manson, JoAnn E, Mary Cushman, Kira C. Taylor (446503), Christopher S. Carlson (108137), Wassertheil-Smoller, Sylvia, Howard, Virginia, Michele M. Sale (3944525), Peyser, Patricia A, Bandera, Elisa V., Ellen W. Demerath (262603), Rotter, Jerome I., Wei-Min Chen, Pettaway, Curtis, Sale, Michele M., Matthew A Allison, Garvey, W Timothy, L Adrienne Cupples, Pettaway, C, Yongmei Liu (104713), Reiner, Alexander P., Fox, Caroline S, et al, +431 morecore +1 more sourceBeneficial Body Mass Index for Age‐Related Kidney Function in Males and Females
AGING MEDICINE, EarlyView.The impact of BMI on age‐related kidney function decline is highly sex‐ and age‐dependent. Normal BMI (18.5–25 kg/m2) is associated with better age‐related kidney function in all‐aged males and females older than 45 years. ABSTRACT Objectives
Kidney function declines with aging, leading to a high prevalence of age‐related disease.Lu Wei, Yao Ma, Xueqi Chen, Xinran Ni, Yu Zhang, Bei Zhu, Qun Zhang, Weihong Zhao +7 morewiley +1 more sourceInflammatory markers in prepubertal children and their associations with abdominal fat
Jornal de PediatriaObjective: To evaluate the association between inflammatory markers and abdominal fat assessed by ultrasound in prepubertal children with and without excess weight. Methods: A cross-sectional study involving 241 prepubertal children, 156 with obesity, 37 Letícia G. de Queiroz, Paulo F. Collett-Solberg, Maria das Graças C. de Souza, Nádia Cristina P. Rodrigues, Alexandra M. Monteiro, Cristiane de S. Mendes, Fernanda M. Gazolla, Cecília L. de Oliveira, Eliete Bouskela, Maria Cristina C. Kuschnir, Isabel R. Madeira +10 moredoaj +1 more sourceValidation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies [PDF]
, 2015 Central obesity is the hallmark of a number of non-inheritable disorders. The advent of imaging techniques such asMRI
has allowed for a fast and accurate assessment of body fat content and distribution.Thomas, E.L., Leinhard, O.D., Borger Magnus, Rosander, J., Borga, M., Romu, T., Bell, J.D., Fitzpatrick, J. +7 morecore +1 more source
