Results 31 to 40 of about 801,934 (258)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Chemical evolution of the intra-cluster medium [PDF]

, 2003
The high metallicity of the intra-cluster medium (ICM) is generally interpreted on the base of the galactic wind scenario for elliptical galaxies. In this framework, we develop a toy-model to follow the chemical evolution of the ICM, formulated in ...
A. Moretti, Abel, Andreon, Andreon, Arimoto, Arimoto, Arnaboldi, Arnaud, Balogh, Becker, Bica, Bressan, Briceño, Bromm, Bryan, C. Chiosi, Carraro, Chabrier, Chiosi, Chiosi, Chiosi, Ciotti, Cirimele, David, David, David, De Grandi, De Propris, De Young, Djorgovski, Driver, Elbaz, Ettori, Ferguson, Ferguson, Finoguenov, Finoguenov, Fukazawa, Fukazawa, Gibson, Gibson, Girardi, Gregg, Greggio, Hernandez, Hinnes, Irwin, Ishimaru, Johnstone, Kaastra, L. Portinari, Lacey, Larson, Larson, Larson, Larson, Lin, Loewenstein, Loewenstein, Luhman, Marigo, Marigo, Martinelli, Martinelli, Matteucci, Matteucci, Matteucci, Matteucci, Matteucci, Mitchell, Mobasher, Mori, Mushotzky, Nath, Padoan, Padoan, Pei, Pipino, Portinari, Press, Reiprich, Renzini, Renzini, Renzini, Roussel, Scalo, Schechter, Serlemitsos, Silk, Smith, Steidel, Tamura, Tantalo, Tinsley, Tornatore, Trentham, Trentham, Trentham, Valdarnini, Vigroux, White, White, White, Woosley, Worthey, Zepf   +105 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Feasibility of following up gamma-hydroxybutyric acid concentrations in sodium oxybate (Xyrem®)-treated narcoleptic patients using dried blood spot sampling at home : an exploratory study [PDF]

, 2013
Background: Gamma-hydroxybutyric acid (GHB), well known as a party drug, especially in Europe, is also legally used (sodium oxybate, Xyrem (R)) to treat a rare sleep disorder, narcolepsy with cataplexy.
Hertegonne, Katrien, Ingels, Ann-Sofie, Lambert, Willy, Stove, Christophe   +3 more
core   +1 more source

Intra-individual variation of sperm DNA fragmentation in the Human ejaculate

Systems Biology in Reproductive Medicine, 2023
This retrospective study assessed the biological intra-individual variability of the percentage of sperm with DNA damage (SDF) observed in subsequent ejaculates of the same individual. Variation in SDF was analyzed using the Mean Signed Difference (MSD) statistic based on 131 individuals, comprising 333 ejaculates.
Mercedes, González-Martínez, Carmen, López-Fernández, Pascual, Sánchez-Martín, Stephen D, Johnston, Jaime, Gosálvez   +4 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Intra-Individual Variation: Significant Changes in Parameters of Lipid and Carbohydrate Metabolism in the Individual and Intra-Individual Variation in Different Test Populations [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1985
Fasting serum triglyceride, cholesterol, HDL cholesterol, HDL2&3 cholesterol, fasting plasma glucose and insulin and haemoglobin A1 were measured under standardised conditions in a group of laboratory volunteers. Intra-individual variation was calculated for each parameter from weekly measurements on at least eleven successive occassions, and the ...
openaire   +2 more sources

Study of inter- and intra-individual variations in the salivary microbiota [PDF]

BMC Genomics, 2010
Oral bacterial communities contain species that promote health and others that have been implicated in oral and/or systemic diseases. Culture-independent approaches provide the best means to assess the diversity of oral bacteria because most of them remain uncultivable.The salivary microbiota from five adults was analyzed at three time-points by means ...
Lazarevic, Vladimir, Whiteson, Katrine, Hernandez, David, Francois, Patrice, Schrenzel, Jacques   +4 more
openaire   +6 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Longitudinal Intra- and Inter-individual variation in T-cell subsets of HIV-infected and uninfected men participating in the LA Multi-Center AIDS Cohort Study. [PDF]

, 2019
To assess the intra-individual and inter-individuals biological variation and the effect of aging on lymphocyte T-cells subsets.We assessed lymphocyte phenotypes (CD3, CD4, and CD8 T-cells) in 89 HIV-1-infected and 88 uninfected white non-Hispanic men ...
Aziz, Najib, Chow, Marianne, Detels, Roger, Jamieson, Beth D, Martinez-Maza, Otoniel, Quint, Joshua J   +5 more
core