Results 151 to 160 of about 151,154 (193)

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Advanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel, Nikolas Ebert, Denis Abu Sammour, Sebastian Graf, Björn C. Fröhlich, Emrullah Birgin, Shad A. Mohammed, Nuh N. Rahbari, Axel Wellmann, Oliver Wasenmüller, Cleo‐Aron Weis, Stefan Schmidt, Carsten Hopf   +12 more
wiley   +1 more source

Bridging data gaps of rare conditions in ICU: a multi-disease adaptation approach for clinical prediction. [PDF]

NPJ Digit Med
Zhu M, Liu Y, Luo Z, Zhu T.
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Early prediction of thyroid capsule invasion in papillary microcarcinoma using ultrasound-based deep learning models: a retrospective multicenter study. [PDF]

Insights Imaging
Sui L, Feng B, Chen X, Jin Z, Zhu X, Jiang T, Yan Y, Zhou Y, Chen C, Yao J, Lai M, Lv L, Wang Y, Wang L, Li C, Feng L, Yue W, Yu D, Shi K, Wang VY, Zhang Y, Xu D.   +21 more
europepmc   +1 more source

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

An interpretable machine learning model for predicting visceral pleural invasion in cT1 lung adenocarcinoma based on habitat analysis. [PDF]

Quant Imaging Med Surg
Gan X, Zhang W, Shen Z, Chen W, Duan X, Dai H, Chen J, Chen B.   +7 more
europepmc   +1 more source

The Dynamic Energy Band Model of Contact‐Separation and Sliding Mode Triboelectric Charging of Polymers at the Metal‐Polymer Interface

Advanced Science, EarlyView.
Triboelectric charge generation at polymer‐metal interfaces arises from the interplay of intra‐ and inter transformation reactions of mechanochemically generated species, physical properties of polymers, environmental conditions. The direction and the magnitude of electron transfer between metal and polymer are dynamically governed by the relative ...
Sunay Dilara Ekim, Zelal Yavuz, Tuğba Demir Çalışkan, Hande Güler, H. Tarik Baytekin   +4 more
wiley   +1 more source

Intratumoural and Peritumoural Radiomics-Based Machine Learning Models for the Postoperative Survival Prediction in Oesophageal Squamous Cell Carcinoma. [PDF]

Interdiscip Cardiovasc Thorac Surg
Deng ZQ, Yang C, Yan ZF, Li Y, Tang HT, Zuo HD, Zhang JJ, Hu WL, Mao YY, Ma DY, Jiang KY, Yan HJ, Tian D.   +12 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source