Results 21 to 30 of about 5,621,565 (249)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Imagery, Affect, and Decision Making [PDF]
, 1998 46 pagesTraditionally, the principal focus of research on judgment and decision making has been largely cognitive and rationalistic. More recently, however, decision-making researchers have acknowledged the role of non-cognitive factors and have ...
Paul Slovic +5 more
core +2 more sources
Intra-cavity field dynamics near avoided mode crossing in concentric silicon nitride ring resonator
, 2020 Understanding the intra-cavity field dynamics in passive microresonator systems has already been intriguing. It becomes fascinating when the system is complex, such as a concentric dual microring resonator that exhibit avoided mode crossing (AMC).
Samudra Roy (14406690) +2 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Fast Depth Intra Mode Decision Based on Mode Analysis in 3D Video Coding
, 2019 Multiview video plus depth (MVD), which consists of a texture image and its associated depth map, has been introduced as a 3D video format, and 3D video coding, such as 3D-HEVC, was developed to efficiently compress this MVD data.
Jin Young Lee
core +1 more source
HEVC’s Intra Mode Selection Using Odds Algorithm
, 2021 International audienceThe brute-force behaviour of High-Efficiency Video Coding (HEVC) is the biggest hurdle in the communication of the multimedia contents.
Rehman, Saad +11 more
core +1 more source