Results 41 to 50 of about 568,973 (334)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Compact 32-Pixel TU-Oriented and SRAM-Free Intra Prediction VLSI Architecture for HEVC Decoder

IEEE Access, 2019
In the High Efficiency Video Coding (HEVC), a variety of CU sizes and intra prediction modes significantly improve coding efficiency, but also bring higher computational complexity.
Yibo Fan, Genwei Tang, Xiaoyang Zeng
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Intra- and peritumoral MRI radiomics assisted in predicting radiochemotherapy response in metastatic cervical lymph nodes of nasopharyngeal cancer

BMC Medical Imaging, 2023
Background To establish and validate radiomic models combining intratumoral (Intra) and peritumoral (Peri) features obtained from pretreatment MRI for the prediction of treatment response of lymph node metastasis from nasopharyngeal cancer (NPC). Methods
Hao Xu, Ai Wang, Chi Zhang, Jing Ren, Peng Zhou, Jieke Liu   +5 more
doaj   +1 more source

Complementary Value of Intra- and Peri-Tumoral PET/CT Radiomics for Outcome Prediction in Head and Neck Cancer

IEEE Access, 2021
To investigate the prognostic value of peri-tumoral radiomics features of pre-treatment PET/CT images in patients with head and neck cancer. 166 patients from 4 centers (111 for training and 55 for external independent testing) were retrospectively ...
Wenbing Lv, Hui Feng, Dongyang Du, Jianhua Ma, Lijun Lu   +4 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Intra-prediction mode decision based on video temporal and spatial correlation

Tongxin xuebao, 2005
An intra-prediction mode-decision method was proposed. Based on the inherent spatial correlation within a single frame and temporal correlation between successive frames, part of intra-prediction modes were chosen to determine the best prediction mode ...
DAI Sheng-kui, YU Li, ZHU Guang-xi, LIU Wen-yu   +3 more
doaj   +2 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

A Complexity Reduction Method for Intra Prediction Method in HEVC Standard

Majlesi Journal of Electrical Engineering, 2022
High Efficiency Video Coding (HEVC) is considered the last standard for video compression with about 50% additional compression compared to the previous standard i.e. H264/AVC, while maintaining image quality.
Zahra Mirian, Mohammadreza Ramezanpour
doaj   +1 more source