Results 211 to 220 of about 2,992,178 (408)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Intracellular order formation through stepwise phase transitions [PDF]

open access: yesarXiv
Living cells inherently exhibit the ability to spontaneously reorganize their structures in response to changes in both their internal and external environments. Among these responses, the organization of stress fibers composed of actin molecules changes in direct accordance with the mechanical stiffness of their environments.
arxiv  

Re-visiting the intracellular pathway of transferrin on board of a mathematical simulation [PDF]

open access: yesarXiv
Modeling and simulation are transforming all fields of biology. Tools like AlphaFold have revolutionized structural biology, while molecular dynamics simulations provide invaluable insights into the behavior of macromolecules in solution or on membranes.
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Innate immunity to intracellular LPS

open access: yesNature Immunology, 2019
V. Rathinam, Yue Zhao, F. Shao
semanticscholar   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

open access: yesFEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya   +3 more
wiley   +1 more source

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