Results 211 to 220 of about 3,321,426 (398)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Redox-responsive peptide folding enables intracellular self-assembly and controlled nucleic acid release. [PDF]

Mater Today Bio
Dong H, Xie W, Huang W, Fang Y, Wang M, Han H, Wu X, Zhang C, Deng J, Yuan D, Shi J.   +10 more
europepmc   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells

, 2013
Michael Hartmann, Andréa Hemmerlin, Elisabet Gas‐Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J. Bach   +6 more
openalex   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Protective Effect of Intracellular Compounds of Lactobacillus plantarum on Goat Sperm Quality During Cryopreservation. [PDF]

Vet Med Sci
Ariyan F, Farzinpour A, Farshad A, Sharifi A.   +3 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

When Matter Builds Itself: Blueprints from Life to Materials. [PDF]

Nano Lett
Aloisio L, Marangi F, Lanzani G.
europepmc   +1 more source

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.

Molecules and Cells, 2017
R. Bagur, G. Hajnóczky
semanticscholar   +1 more source

Peer Review #1 of "Differential effects of cotreatment of the antibiotic rifampin with host-directed therapeutics in reducing intracellular Staphylococcus aureus infection (v0.1)"

, 2020
Melissa D. Evans, Robert Erik Sammelson, Susan A. McDowell, S Tong, J Davis, E Eichenberger, T Holland, V Fowler, N Kavanagh, E Ryan, A Widaa, G Sexton, J Fennell, S O'rourke, K Cahill, C Kearney, F O'brien, S Kerrigan, C Goss, M Muhlebach, D Armstrong, K Grimwood, J Carlin, R Carzino, J Gutierrez, J Hull, A Olinsky, E Phelan, C Robertson, P Phelan, C Branger, C Gardye, N Lambert-Zechovsky, M Schwerdt, C Neumann, B Schwartbeck, S Kampmeier, S Herzog, D Gorlich, A Dubbers, J Grosse-Onnebrink, C Kessler, P Kuster, H Schultingkemper, J Treffon, G Peters, B Kahl, J Hatzenbuehler, T Pulling, B Loffler, L Tuchscherr, S Niemann, G Peters, R Proctor, C Eiff, B Kahl, K Becker, P Mcnamara, M Herrmann, G Peters, L Tuchscherr, E Medina, M Hussain, W Volker, V Heitmann, S Niemann, D Holzinger, J Roth, R Proctor, K Becker, G Peters, B Loffler, T Foster, J Geoghegan, V Ganesh, M Hook, M Horn, S Knecht, F Rushing, J Birdsong, C Siddall, C Johnson, T Abraham, A Brown, C Volk, K Gammon, D Bishop, J Mckillip, S Mcdowell, F Agerer, S Lux, A Michel, M Rohde, K Ohlsen, C Hauck, C Nobes, A Hall, L Arbibe, J Mira, N Teusch   +99 more
openalex   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source