Results 301 to 310 of about 3,143,322 (333)

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake. [PDF]

Cancer Drug Resist
Sandu K, Warta R, Biswas U, Zhang W, Michl P, Herold-Mende C, Weiss J, Theile D.   +7 more
europepmc   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

CRISPR <i>cas7</i> influences the host-pathogen interaction of <i>Porphyromonas gingivalis</i>. [PDF]

J Oral Microbiol
de Mello Fiallos N, Irfan M, Solbiati J, R Walker A, Frias-Lopez J, Gibson FC.   +5 more
europepmc   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

EPP1 is an ancestral component of the plant Common Symbiosis Pathway

Rich M, Vernié T, Tiwari M, Chauderon L, Causse J, Pellen T, Boussaroque A, Bianconi ME, Vandenbussche M, Chambrier P, Le Ru A, Castel B, Nagalla S, Cullimore J, Keller J, Valdes-Lopez O, Mbengue M, Ané J, Delaux P.   +18 more
europepmc   +1 more source

Global constraint principle for microbial growth laws. [PDF]

Proc Natl Acad Sci U S A
Yamagishi JF, Hatakeyama TS.
europepmc   +1 more source

OTUB1 Modulates Ferroptosis by Regulating SLC7A11 Ubiquitination in Pancreatic β-Cells. [PDF]

FASEB J
Yoo S, Kim D, Kim M, Bae JY, Lee SA, Kim ET, Koh G.   +6 more
europepmc   +1 more source

Targeting intracellular of populations Pseudomonas aeruginosa with peptide-mimetic therapies: individual efficacy and synergistic rescue of obsolete antibiotics

Burger ML, Doyle R, Lin JS, Barron AE, Moule MG.   +4 more
europepmc   +1 more source

Zinc, Soluble Epoxide Hydrolase, and the Pulmonary Vascular Paradox: Novel Insights into a Well-Known Phenomenon. [PDF]

Am J Respir Crit Care Med
Zhao L, Wilkins MR.
europepmc   +1 more source