Results 301 to 310 of about 2,142,587 (349)
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Intracellular Cholesterol Trafficking
Cold Spring Harbor Perspectives in Biology, 2023Cholesterol is an essential lipid species of mammalian cells. Cells acquire it through synthesis in the endoplasmic reticulum (ER) and uptake from lipoprotein particles. Newly synthesized cholesterol is efficiently distributed from the ER to other organelles via lipid-binding/transfer proteins concentrated at membrane contact sites (MCSs) to reach the ...
Ikonen Elina, Olkkonen Vesa M.
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Current Opinion in Neurobiology, 1994
Intracellular channels are located on the membranes of intracellular organelles and are involved in ion transfer, within the cytosolic compartments, in response to internal stimuli. Recently, various types of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca(2+)-release channels, mitochondrial voltage-dependent anion channels, and a vesicular Cl-
T, Furuichi +3 more
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Intracellular channels are located on the membranes of intracellular organelles and are involved in ion transfer, within the cytosolic compartments, in response to internal stimuli. Recently, various types of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca(2+)-release channels, mitochondrial voltage-dependent anion channels, and a vesicular Cl-
T, Furuichi +3 more
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Current Protocols in Cytometry, 2004
AbstractThe principal technique described in this unit was developed for detecting cytokines produced by T cells, specifically interferon gamma (IFN‐γ) and interleukin 4 (IL‐4). In addition to providing information about which cytokines are being produced, it also helps to phenotypically identify the specific cells producing them.
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AbstractThe principal technique described in this unit was developed for detecting cytokines produced by T cells, specifically interferon gamma (IFN‐γ) and interleukin 4 (IL‐4). In addition to providing information about which cytokines are being produced, it also helps to phenotypically identify the specific cells producing them.
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Trends in Genetics, 1999
Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell cycle, in signal transduction and in
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Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell cycle, in signal transduction and in
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Respiration Physiology, 1978
In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity with respect to pH in vivo could ...
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In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity with respect to pH in vivo could ...
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2017
The macula is predisposed to edema in various retinal conditions, even when the insult is remote from the macula. The various factors that may predispose the macula to edema include high metabolic activity, radial arrangement of the Henle's layer, lack of inner layers at the fovea, and lack of blood supply at the fovea.
Raja, Narayanan, Baruch D, Kuppermann
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The macula is predisposed to edema in various retinal conditions, even when the insult is remote from the macula. The various factors that may predispose the macula to edema include high metabolic activity, radial arrangement of the Henle's layer, lack of inner layers at the fovea, and lack of blood supply at the fovea.
Raja, Narayanan, Baruch D, Kuppermann
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Targeting Intracellular Targets
Current Drug Delivery, 2004Many therapeutic agents have intracellular compartments as their site of action. Targeted delivery of these agents to their specific intracellular targets could result in enhanced therapeutic efficacy and reduced toxicity. Various carriers have been shown useful in targeted delivery of different classes of therapeutic agents.
Jayanth, Panyam, Vinod, Labhasetwar
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Nature Reviews Immunology, 2010
The recognition of nucleic acids is one strategy by which cells can detect infectious agents. As life is ultimately determined by the existence of nucleic acids, this defence strategy has evolved in many different organisms and operates effectively in many different cell types.
Veit Hornung, Eicke Latz
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The recognition of nucleic acids is one strategy by which cells can detect infectious agents. As life is ultimately determined by the existence of nucleic acids, this defence strategy has evolved in many different organisms and operates effectively in many different cell types.
Veit Hornung, Eicke Latz
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Cellular and Molecular Life Sciences, 2000
Water often acts as a critical reactant in cellular reactions. Its role can be detected by modulating water activity with osmotic agents. We describe the principles behind this 'osmotic stress' strategy, and survey the ubiquity of water effects on molecular structures that have aqueous, solute-excluding regions.
R P, Rand, V A, Parsegian, D C, Rau
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Water often acts as a critical reactant in cellular reactions. Its role can be detected by modulating water activity with osmotic agents. We describe the principles behind this 'osmotic stress' strategy, and survey the ubiquity of water effects on molecular structures that have aqueous, solute-excluding regions.
R P, Rand, V A, Parsegian, D C, Rau
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Intracellular Calcium Homeostasis
Annual Review of Biochemistry, 1987CALCIUM BUFFERING BY THE CYTOSOLIC HIGH-AFFINITY CALCIUM-BINDING PROTEINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . THE MEASUREMENT OF INTRACELLULAR FREE CALCIUM . . . . . . . . . . . . . . . . . . . . . . . MEMBRANE TRANSPORT OF CALCIUM . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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