Results 61 to 70 of about 796,901 (292)

High‐Efficient and Dosage‐Controllable Intracellular Cargo Delivery through Electrochemical Metal–Organic Hybrid Nanogates

Small Science, 2021
Hollow nanostructures combined with electroporation are potentially valuable in interdisciplinary fields due to their ability to transport versatile cargos into adhesive cells.
Bowen Zhang, Dinuo Zheng, Shi Yiming, Kazuhiro Oyama, Masahiro Ito, Masaomi Ikari, Takanori Kigawa, Tsutomu Mikawa, Takeo Miyake   +8 more
doaj   +1 more source

Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability. [PDF]

PLoS ONE, 2012
It is hypothesized that high frequency components of nanosecond pulsed electric fields (nsPEFs), determined by transient pulse features, are important for maximizing electric field interactions with intracellular structures.
Stephen J Beebe, Yeong-Jer Chen, Nova M Sain, Karl H Schoenbach, Shu Xiao   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Galectin-3 (MAC-2) controls phagocytosis and macropinocytosis through intracellular and extracellular mechanisms

Frontiers in Cellular Neuroscience, 2022
Galectin-3 (Gal-3; formally named MAC-2) is a β-galactoside-binding lectin. Various cell types produce Gal-3 under either normal conditions and/or pathological conditions. Gal-3 can be present in cells' nuclei and cytoplasm, secreted from producing cells,
Shlomo Rotshenker
doaj   +1 more source

Chloride intracellular channel 3: a secreted pro-invasive oxidoreductase [PDF]

, 2017
No abstract ...
Norman, Jim, Zanivan, Sara
core   +1 more source

Membrane Trafficking: Intracellular Highways and Country Roads [PDF]

Plant Physiology, 2008
Membrane trafficking, or the flow of membrane material between endomembrane compartments and the plasmalemma, is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell.
Cheung, A.Y., de Vries, S.C.
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]

, 2015
Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn, Andrade-Gordon, Andrews, Bae, Bae, Bae, Bernatowicz, Capodanno, Chackalamannil, Chandra C. Ghosh, Chris Dockendorff, Christian G. Peters, Connolly, Covic, Dockendorff, Dowal, Garcia, Griffin, James R. Dilks, Karen De Ceunynck, Kataoka, Katritch, Knezevic, Kosoglou, Kosoglou, Lee, Matsuoka, May, McCoy, Mingdong Huang, Moers, Morrow, Mosnier, Mosnier, Mosnier, Nicholls, Offermanns, Omozuanvbo Aisiku, O’Callaghan, O’Donoghue, Riewald, Riewald, Robert Flaumenhaft, Salchow, Samir M. Parikh, Susanna F. Fustolo-Gunnink, Swift, Taylor, Tressel, Tricoci, Vanhoorelbeke, Wiviott, Zhang   +52 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source