Results 91 to 100 of about 198,097 (261)

Structural and functional investigation of the cytoplasmic domain of the Fas death receptor [PDF]

, 2015
Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core  

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

The Anti-inflammatory mechanisms of Hsp70

Frontiers in Immunology, 2012
Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such responses is only now becoming clear.
Thiago J Borges, Lotte eWieten, Martijn J C van Herwijnen, Femke eBroere, Ruurd eVan Der Zee, Cristina eBonorino, Willem eVan Eden   +6 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Unlocking the potential of garlic by-product protein: Ultrasound-induced structural modification and fabrication of an ACE inhibitory peptide targeting endothelial dysfunction

Ultrasonics Sonochemistry
This study aimed to explore the potential of ultrasound pretreatment to modify garlic by-product proteins and assist in the production of angiotensin I-converting enzyme (ACE) inhibitory peptides with protective effects against endothelial dysfunction ...
Lu Xiang, Zhichang Qiu, Zhenjia Zheng, Haihua Chen, Yiteng Qiao   +4 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Analysis of Drosophila Fibroblast Growth Factor Functional Domains [PDF]

, 2011
The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease.
Tulin, Sarah Lynn
core   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA [PDF]

, 2012
Conradi J, Tegtmeyer N, Wozna M, et al. An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Frontiers in Cellular and Infection Microbiology.
Backert, Steffen, Tegtmeyer, Nicole, Timothy L Cover, Steffen Backert, Gagell, Corinna, Marta eWoźna, Marco eWissbrock, Cover, Timothy L., Sewald, Norbert ; https://orcid.org/, Michalek, Carmela, Frank, Ronald, Ronald eFrank, Norbert eSewald, Jens eConradi, Nicole Tegtmeyer, Carmela Michalek, Corinna eGagell, Jens Conradi, Steffen eBackert, Norbert Sewald, Carmela eMichalek, Marco Wissbrock, Wißbrock, Marco, Timothy L. Cover, Wozna, Marta, Marta Woźna, Corinna Gagell, Ronald Frank, Conradi, Jens, Nicole eTegtmeyer   +29 more
core   +1 more source

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

Journal of Lipid Research, 2006
It has been suggested that the signal transduction initiated by apolipoprotein A-I (apoA-I) activates key proteins involved in cholesterol efflux. ABCA1 serves as a binding partner for apoA-I, but its participation in apoA-I-induced signaling remains ...
Jerzy-Roch Nofer, Alan T. Remaley, Renata Feuerborn, Iza Wolinnéska, Thomas Engel, Arnold von Eckardstein, Gerd Assmann   +6 more
doaj   +1 more source