Results 91 to 100 of about 84,766 (305)

Prostaglandin E-2-EP2-NF-kappa B signaling in macrophages as a potential therapeutic target for intracranial aneurysms [PDF]

, 2017
Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is ...
Aoki, Tomohiro, Bando, Kana, Frösen, Juhana, Fukuda, Miyuki, Laakkonen, Johanna, Narumiya, Shuh, Nozaki, Kazuhiko, Ollikainen, Eliisa, Shioi, Go, Tsuji, Keiichi   +9 more
core   +1 more source

Elucidating the etiology of idiopathic spontaneous intraperitoneal hemorrhage

Journal of Forensic Sciences, EarlyView.
Abstract Free blood within the abdominal cavity (hemoperitoneum) presents a significant diagnostic and interpretive challenge. It may result from trauma or occur spontaneously in association with underlying disease conditions. When no source of fatal hemorrhage is identified, the implications extend across forensic, criminalistic, legal, and ethical ...
Dalibor Kovařík, Štěpánka Pohlová Kučerová, Lenka Zátopková, Petr Hejna, Martin Janík   +4 more
wiley   +1 more source

Extending the indications of flow diversion to small, unruptured, saccular aneurysms of the anterior circulation. [PDF]

, 2014
BACKGROUND AND PURPOSE: Flow diverters are currently indicated for treatment of large and complex intracranial aneurysms. The purpose of this study was to determine whether the indications of flow diversion can be safely extended to unruptured, small ...
Bovenzi, Cory D, Chalouhi, MD, Nohra, Gonzalez, L. Fernando, Hasan, David, Jabbour, Pascal, MD, Rosenwasswer MD, Robert H., Starke, Robert M, Tjoumakaris, Stavropoula, Yang, Steven   +8 more
core   +1 more source

First Direct Evidence of Accelerated Molecular Aging in Intracranial Aneurysmal Tissue

Aging Cell, EarlyView.
This study provides the first direct evidence of accelerated molecular aging in human intracranial aneurysm tissue, marked by telomere shortening, oxidative DNA damage, and activation of mTOR and NF‐κB pathways. These findings reveal critical aging‐related mechanisms potentially driving aneurysm formation and rupture.
Dilaware Khan, Xuanchen Li, Michael Hewera, Sajjad Muhammad   +3 more
wiley   +1 more source

Spectrophotometry for cerebrospinal fluid pigment analysis [PDF]

, 2006
The use of spectrophotometry for the analysis of the cerebrospinal fluid (CSF) is reviewed. The clinically relevant CSF pigments--oxyhemoglobin and bilirubin--are introduced and discussed with regard to clinical differential diagnosis and potentially ...
Keir, G., Petzold, A., Sharpe, L.T.
core   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Non-Newtonian and flow pulsatility effects in simulation models of a stented intracranial aneurysm [PDF]

, 2011
Permission to redistribute provided by publishers.Three models of different stent designs implanted in a cerebral aneurysm, originating from the Virtual Intracranial Stenting Challenge'07, are meshed and the flow characteristics simulated using ...
Atherton M. A., G S Barozzi, Karmonik C., M A Atherton, M Cavazzuti, M W Collins, Owen I., Shibeshi S. S., Steinman D. A.   +8 more
core   +1 more source

Biallelic COL4A2 Variants Associated With Brain Small Vessel Disease and Brain Malformations

Clinical Genetics, EarlyView.
Biallelic COL4A2 variants cause a spectrum of brain abnormalities such as brain small vessel disease (BSVD). We describe two cases—one with cerebrovascular disruption and one with cortical malformations—expanding the recessive phenotype. Protein modeling reveals destabilization by p.(Arg179Cys), reinforcing its pathogenic role and highlighting collagen
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Reihaneh Khorasanian, Mariasavina Severino, Morteza Doustmohammadi, Francesca Madia, Siddharth Srivastava, Aisling Quinlan, Dario Paladini, Federico Zara, Marcello Scala   +11 more
wiley   +1 more source

Morphological Characteristics of Intracranial Aneurysms and Applicability of CT Angiography in Risk Assessment of Rupture

CT Lilun yu yingyong yanjiu
Objective: To explore the application value and morphological characteristics of CT angiography (CTA) in the risk assessment of intracranial aneurysm rupture.
Qian WANG, Shikui SHI
doaj   +1 more source

Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Persistent headache (PH) after an aneurysmal subarachnoid hemorrhage (aSAH) and the influence of migraine history (MH) on its evolution and prognosis is poorly understood. Our study aims are to (1) determine the prevalence, characteristics, and prognostic factors of PH after aSAH; and (2) study the impact of personal MH ...
Laura Gómez‐Dabó, Víctor J. Gallardo, Daniel Campos‐Fernández, Marc Rodrigo‐Gisbert, Maider Iza‐Achutegui, Anna Sánchez, Fuat Arikan, Estevo Santamarina, Edoardo Caronna, Patricia Pozo‐Rosich   +9 more
wiley   +1 more source