Results 1 to 10 of about 5,934 (136)

Intracranial arteriosclerosis is not associated with cerebral amyloid deposition [PDF]

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
BACKGROUND Intracranial arteriosclerosis and cerebral amyloid beta (Aβ) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.
Anna M Streiber, Julia Neitzel, Meike W Vernooij   +2 more
exaly   +6 more sources

Prevalence, volume, and clinical correlates of intracranial arteriosclerosis among patients with cognitive complaints: a clinic‐based study [PDF]

Alzheimer's and Dementia
Abstract Background Intracranial arteriosclerosis increases the risk of dementia in the general population, but no published studies have determined its clinical value for the diagnosis of vascular cognitive impairment in a memory clinic setting. Method We included 317 patients (mean age: 69.9 years, 44% female) who attended the Erasmus MC Alzheimer ...
Meike W Vernooij, Esther Van Den Berg, Daniel Bos   +2 more
exaly   +6 more sources

Intracranial arterial calcification and cerebrovascular function in the general aging population – A 7T MRI Study [PDF]

Cerebral Circulation - Cognition and Behavior
Background: Intracranial arteriosclerosis may impair downstream cerebrovascular function, but the underlying mechanisms remain unclear. Using 7T MRI, we investigate the association between intracranial arteriosclerosis and cerebrovascular function in the
Anna M. Streiber, Carmen Kuenen, Stanley D.T. Pham, Julia Neitzel, Daniel Bos, Jeroen C.W. Siero, Jaco J.M. Zwanenburg, Nikki Dieleman, Geert Jan Biessels, Meike W. Vernooij   +9 more
doaj   +2 more sources

Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We evaluated associations between an in vivo (magnetic resonance imaging [MRI]) marker of arteriolosclerosis (ARTS) and multimodal neuroimaging and plasma ATN(V) biomarkers. METHODS Among 238 participants with both amyloid and tau positron emission tomography (PET) scans within 1 year of MRI, we examined multivariable adjusted ...
Rudolph MD, Lockhart SN, Rundle MR, Barcus RA, Alphin KH, Bateman JR, Sai KKS, Mielke MM, Register TC, Craft S, Risacher SL, Hughes TM.   +11 more
europepmc   +2 more sources

A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score. [PDF]

CNS Neurosci Ther
This study developed and validated the novel AHOC score, a simple pre‐thrombectomy tool for predicting stroke etiology (embolism vs. intracranial atherosclerosis) in acute middle cerebral artery occlusion. This score integrates four key clinical/imaging variables—atrial fibrillation, hyperdense artery sign, stenosis/occlusion in other arteries, and ...
Zhang H, Su Y, Xu Z, Chen Y, Yang R, Gan W, Huang Z, Cai L, Zeng C, Huang Q, Zhang J, Zou K, Huang J, Fang P, Li X, Fan Y, Hong D, Lin J.   +17 more
europepmc   +2 more sources

Letter to the Editor: Reaffirming Caution-The Unacceptable Vasoconstrictive Risk of CGRP-Related Therapies in Moyamoya Angiopathy. [PDF]

Eur J Neurol
European Journal of Neurology, Volume 33, Issue 1, January 2026.
Gaul C, Naegel S.
europepmc   +2 more sources

Ventriculomegaly without elevated intracranial pressure? Normal pressure hydrocephalus as a disorder of the cerebral windkessel [PDF]

Frontiers in Neurology
ObjectiveNormal pressure hydrocephalus (NPH) is characterized by ventriculomegaly without elevations in intracranial pressure (ICP). One way of viewing hydrocephalus is as a disorder of the cerebral windkessel.
Racheed Mani, Racheed Mani, Jade Basem, Liu Yang, Liu Yang, Nahid Shirdel Abdolmaleki, Anand Ravishankar, Susan Fiore, Petar Djuric, Michael Egnor   +9 more
doaj   +2 more sources

Impact of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on intracranial atherosclerotic plaque characteristics and low density lipoprotein-cholesterol (LDL-C) reduction: a real-world observational study [PDF]

PeerJ
Background and purpose The combination of PCSK9 inhibitors and moderate statin therapy effectively stabilizes intracranial atherosclerotic plaques in patients with intracranial atherosclerotic stenosis (ICAS).
Zhenzhen Li, Xiaohui Li, Yiting Zhang, Jingwen Qi, Lifan Ji, Shuo Li, Mengmeng Gu, Yukai Liu, Yuqiao Zhang, Yanping Mei, Meng Wang, Junshan Zhou, Mouxiao Su, Lin Zhu, Qiwen Deng   +14 more
doaj   +3 more sources

Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients [PDF]

Fluids and Barriers of the CNS
Background Cerebral autoregulation is a robust regulatory mechanism that stabilizes cerebral blood flow in response to reduced blood pressure, thereby preventing cerebral ischaemia.
Tomohisa Ohmura, Yoshinaga Kajimoto, Masahiro Kameda, Masatsugu Kamo, Ryokichi Yagi, Ryo Hiramatsu, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Toshihiro Takami, Hiroji Miyake, Toshihiko Kuroiwa, Marek Czosnyka, Masahiko Wanibuchi   +13 more
doaj   +2 more sources

Review of theories into the pathogenesis of normal pressure hydrocephalus [PDF]

BMJ Neurology Open
Normal pressure hydrocephalus (NPH) represents a unique form of hydrocephalus characterised by the paradox of ventriculomegaly without significant elevations in intracranial pressure, with the clinical triad of gait instability, cognitive impairment, and
Liu Yang, Racheed Mani, Jade Basem, Susan Fiore, Petar Djuric, Michael Egnor   +5 more
doaj   +2 more sources