Results 11 to 20 of about 9,913 (190)

Intracranial arteriosclerosis is related to cerebral small vessel disease: a prospective cohort study [PDF]

Neurobiology of Aging, 2021
Intracranial arteriosclerosis has been increasingly recognized as a risk factor for cognitive impairment and even dementia. A possible mechanism linking intracranial arteriosclerosis to cognitive impairment and dementia involves structural brain changes including cerebral small vessel disease (CSVD).
Elisabeth J. Vinke, Pinar Yilmaz, Janine E. van der Toorn, Rahman Fakhry, Kate Frenzen, Florian Dubost, Silvan Licher, Marleen de Bruijne, Maryam Kavousi, M. Arfan Ikram, Meike W. Vernooij, Daniel Bos   +11 more
openaire   +6 more sources

Intracranial Carotid Arteriosclerosis Mediates the Association Between Blood Pressure and Cerebral Small Vessel Disease

Hypertension, 2023
Background: Intracranial arteriosclerosis could explain the association between blood pressure (BP) and cerebral small vessel disease (CSVD). Therefore, we tested whether intracranial carotid artery calcification (ICAC) mediates the association between BP and CSVD and determined pathophysiological mechanisms ...
Melgarejo, Jesus D., Vernooij, Meike W., Ikram, M. Arfan, Zhang, Zhen-Yu, Bos, Daniel   +4 more
exaly   +7 more sources

Morphological Subtypes of Intracranial Internal Carotid Artery Arteriosclerosis and the Risk of Stroke

Stroke, 2022
Background: Accumulating evidence highlights the existence of distinct morphological subtypes of intracranial carotid arteriosclerosis. So far, little is known on the prevalence of these subtypes and subsequent stroke risk in the general population.
Tim C. van den Beukel, Janine E. van der Toorn, Meike W. Vernooij, Maryam Kavousi, Ali C. Akyildiz, Pim A. de Jong, Aad van der Lugt, M. Kamran Ikram, Daniel Bos   +8 more
openaire   +7 more sources

Impact of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on intracranial atherosclerotic plaque characteristics and low density lipoprotein-cholesterol (LDL-C) reduction: a real-world observational study [PDF]

PeerJ
Background and purpose The combination of PCSK9 inhibitors and moderate statin therapy effectively stabilizes intracranial atherosclerotic plaques in patients with intracranial atherosclerotic stenosis (ICAS).
Zhenzhen Li, Xiaohui Li, Yiting Zhang, Jingwen Qi, Lifan Ji, Shuo Li, Mengmeng Gu, Yukai Liu, Yuqiao Zhang, Yanping Mei, Meng Wang, Junshan Zhou, Mouxiao Su, Lin Zhu, Qiwen Deng   +14 more
doaj   +3 more sources

Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients [PDF]

Fluids and Barriers of the CNS
Background Cerebral autoregulation is a robust regulatory mechanism that stabilizes cerebral blood flow in response to reduced blood pressure, thereby preventing cerebral ischaemia.
Tomohisa Ohmura, Yoshinaga Kajimoto, Masahiro Kameda, Masatsugu Kamo, Ryokichi Yagi, Ryo Hiramatsu, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Toshihiro Takami, Hiroji Miyake, Toshihiko Kuroiwa, Marek Czosnyka, Masahiko Wanibuchi   +13 more
doaj   +2 more sources

Review of theories into the pathogenesis of normal pressure hydrocephalus [PDF]

BMJ Neurology Open
Normal pressure hydrocephalus (NPH) represents a unique form of hydrocephalus characterised by the paradox of ventriculomegaly without significant elevations in intracranial pressure, with the clinical triad of gait instability, cognitive impairment, and
Liu Yang, Racheed Mani, Jade Basem, Susan Fiore, Petar Djuric, Michael Egnor   +5 more
doaj   +2 more sources

A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score. [PDF]

CNS Neurosci Ther
This study developed and validated the novel AHOC score, a simple pre‐thrombectomy tool for predicting stroke etiology (embolism vs. intracranial atherosclerosis) in acute middle cerebral artery occlusion. This score integrates four key clinical/imaging variables—atrial fibrillation, hyperdense artery sign, stenosis/occlusion in other arteries, and ...
Zhang H, Su Y, Xu Z, Chen Y, Yang R, Gan W, Huang Z, Cai L, Zeng C, Huang Q, Zhang J, Zou K, Huang J, Fang P, Li X, Fan Y, Hong D, Lin J.   +17 more
europepmc   +2 more sources

Letter to the Editor: Reaffirming Caution-The Unacceptable Vasoconstrictive Risk of CGRP-Related Therapies in Moyamoya Angiopathy. [PDF]

Eur J Neurol
European Journal of Neurology, Volume 33, Issue 1, January 2026.
Gaul C, Naegel S.
europepmc   +2 more sources

Endovascular Treatment of Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease [PDF]

Journal of Stroke, 2022
Mechanical thrombectomy (MT) has become the gold-standard for patients with acute large vessel occlusion strokes (LVOS). MT is highly effective in the treatment of embolic occlusions; however, underlying intracranial atherosclerotic disease (ICAD ...
Jin Soo Lee, Seong-Joon Lee, Ji Man Hong, Francisco José Arruda Mont Alverne, Fabricio Oliveira Lima, Raul G. Nogueira   +5 more
doaj   +1 more source

Intracranial arteriosclerosis and the risk of dementia: A population‐based cohort study

Alzheimer's & Dementia, 2023
AbstractBACKGROUNDThe impact of intracranial arteriosclerosis on dementia remains largely unclear.METHODSIn 2339 stroke‐free and dementia‐free participants (52.2% women, mean age 69.5 years) from the general population, we assessed intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC) as proxy for ...
van den Beukel, Tim C., Wolters, Frank J., Siebert, Uwe, Spiering, Wilko, Ikram, M. Arfan, Vernooij, Meike W., de Jong, Pim A., Bos, Daniel   +7 more
openaire   +3 more sources