Results 81 to 90 of about 9,913 (190)

Mathematical modeling of thrombus formation in idealized models of aortic dissection: Initial findings and potential applications [PDF]

, 2016
Aortic dissection is a major aortic catastrophe with a high morbidity and mortality risk caused by the formation of a tear in the aortic wall. The development of a second blood filled region defined as the “false lumen” causes highly disturbed flow ...
Menichini, C, Xu, XY
core   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang, Weiwei Jiang, Xiongquan Long, Peng Mao, Pingping He, Xinping Ouyang   +5 more
wiley   +1 more source

C-factor: a summary measure for systemic arterial calcifications

BMC Cardiovascular Disorders, 2021
Background Arterial calcification, the hallmark of arteriosclerosis, has a widespread distribution in the human body with only moderate correlation among sites.
Lieke M. Kuiper, M. Kamran Ikram, Maryam Kavousi, Meike W. Vernooij, M. Arfan Ikram, Daniel Bos   +5 more
doaj   +1 more source

Hemodynamic Measurement Using Four-Dimensional Phase-Contrast MRI: Quantification of Hemodynamic Parameters and Clinical Applications [PDF]

, 2019
Recent improvements have been made to the use of time-resolved, three-dimensional phase-contrast (PC) magnetic resonance imaging (MRI), which is also named four-dimensional (4D) PC-MRI or 4D flow MRI, in the investigation of spatial and temporal ...
Ha, H, Kim, GB, Kim, N, Kim, YH, Kweon, J, Lee, DH, Lee, SJ, Yang, DH   +7 more
core   +1 more source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear. METHODS Using a large dataset (n = 763 GENFI2 participants), we measured WMHs and examined them across genetic FTD variants and ...
Mahdie Soltaninejad, Mahsa Dadar, D. Louis Collins, Reza Rajabli, Vikram Venkatraghavan, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry‐Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez‐Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Yasser Iturria‐Medina, Simon Ducharme, GENFI Consortium   +38 more
wiley   +1 more source

Clinical effect analysis of recanalization treatment for acute ischemic stroke with large infarct core caused by intracranial atherosclerotic stenosis and cardiac embolism

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the short ⁃ term efficacy, long ⁃ term outcome and safety of recanalization treatment in patients with acute ischemic stroke presenting with large infarct core caused by intracranial atherosclerotic stenosis (ICAS) versus ...
ZHU Jin⁃zhao, XIE Wei⁃zheng, ZHANG Jian⁃gang, FENG Guang   +3 more
doaj   +1 more source

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke [PDF]

, 2014
BACKGROUND: This is an updated version of the original Cochrane review published in 2010, Issue 1. Seizures after stroke are an important clinical problem, and they may be associated with poor outcome.
Kwan, SKJ, Sykes, L, Wood, E
core   +1 more source

Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid‐beta (Aβ) deposition and tau pathology. Although disease‐modifying therapies, such as anti‐Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain‐
Jiangwei Ding, Chengbin Zhao, Xiaoyan Hao, Hongliang Jiao   +3 more
wiley   +1 more source

Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions

MedComm, Volume 6, Issue 10, October 2025.
PROTACs are reshaping drug discovery through targeted protein degradation. Clinical programs now extend to prostate, breast, lung, hematologic, and solid tumors, with key targets including AR, ER, BTK, STAT3, Bcl‐xL, BRD9, Kras, and so on. These degraders overcome resistance, broaden therapeutic scope, and provide solutions for “undruggable” proteins ...
Gang Fan, Shilin Chen, Qingping Zhang, Na Yu, Ziyang Shen, Zhaoji Liu, Weiming Guo, Zhihan Tang, Jing Yang, Miao Liu   +9 more
wiley   +1 more source

Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik, Uma Athale, Markus Metzler, Frederic Millot, Meinolf Suttorp   +4 more
wiley   +1 more source