Results 61 to 70 of about 5,934 (136)

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Markers of Giant Cell Arteritis in Patients Presenting With Ischemic Stroke: A Scoping Review

European Journal of Neurology, Volume 32, Issue 12, December 2025.
Giant cell arteritis should be considered in patients aged ≥ 50 years presenting with vertebrobasilar ischemic events, multifocal infarcts affecting both vertebrobasilar and carotid territories, or recurrent ischemic events despite optimal secondary prevention.
Alain‐Mauricio Vergara, Marco Perez‐Caceres, Maxime Chayer‐Lanthier, Carolyn Ross, Jean‐Paul Makhzoum, Sylvain Lanthier   +5 more
wiley   +1 more source

Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology – particularly amyloid beta (Aβ), tau, and vascular changes – with corresponding retinal changes.
M. Amin Banihashemi, Saffire H. Krance, Patrick Xiang Ji, Morgan Koo, Julie Ottoy, Richard H. Swartz, Peter J. Kertes, Christopher Hudson, Maged Goubran, Sandra E. Black   +9 more
wiley   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang, Weiwei Jiang, Xiongquan Long, Peng Mao, Pingping He, Xinping Ouyang   +5 more
wiley   +1 more source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear. METHODS Using a large dataset (n = 763 GENFI2 participants), we measured WMHs and examined them across genetic FTD variants and ...
Mahdie Soltaninejad, Mahsa Dadar, D. Louis Collins, Reza Rajabli, Vikram Venkatraghavan, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry‐Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez‐Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Yasser Iturria‐Medina, Simon Ducharme, GENFI Consortium   +38 more
wiley   +1 more source

Is there a consistent association between coronary heart disease and ischemic stroke caused by intracranial atherosclerosis? Existe uma associação consistente entre doença coronária e acidente vascular cerebral isquêmico causado por aterosclerose intracraniana?

Arquivos de Neuro-Psiquiatria, 2013
Coronary heart disease and ischemic stroke are frequent coexistent conditions that share risk factors and pose major burdens to global health. Even though a clear relation has been established between extracranial internal carotid artery atherosclerosis ...
Adriana B. Conforto, Claudia da Costa Leite, Cesar H. Nomura, Edson Bor-Seng-Shu, Raul D. Santos   +4 more
doaj  

Endovascular Therapy for Acute Basilar Artery Occlusion: Comparison between Patients with and without Underlying Intracranial Atherosclerotic Stenosis

대한영상의학회지, 2017
Purpose To compare the characteristics and outcomes of multimodal endovascular therapy (EVT) in patients with acute basilar artery occlusion (BAO) with and without underlying intracranial atherosclerotic stenosis (ICAS).
Gun Soo Kim, Seul Kee Kim, Byeong Hyeon Baek, Youn Young Lee, Woong Yoon   +4 more
doaj   +1 more source

Espasmo hemifacial familiar: relato de dois casos Familial hemifacial spasm: report of two cases

Arquivos de Neuro-Psiquiatria, 1998
Os autores relatam os achados clínicos e angiográficos de dois casos de espasmo hemifacial familiar. Esta é a quinta descrição sobre esse tema na literatura e apresenta mãe e filha com idades de 76 e 51 anos respectivamente, nas quais o lado esquerdo foi
EGBERTO REIS BARBOSA, MARIA DO DESTERRO L. DA COSTA, CLÁUDIO C. STAUT, LUIZ ALBERTO BACHESCHI, MIRIAM SALVATORI BITTAR   +4 more
doaj   +1 more source

Risk factors of in⁃stent restenosis for intracranial artery stenosis: a Meta⁃analysis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To assess the risk factors of in-stent restenosis (ISR) for intracranial artery stenosis by Meta-analysis. Methods Retrieve relevant case-control studies or cohort studies from online databases (January 1, 1990-August 1, 2017) as PubMed, EBMASE/
Qian LI, Da XU, Deng CHEN, Li⁃na ZHU, Hai⁃jiao WANG, Ge TAN, Yu ZHANG, Ling LIU   +7 more
doaj  

Intracranial Pressure and Vascular Aging: A Narrative Review on its Role in Monitoring Cognitive Decline

Artery Research
Vascular aging is closely associated with the development of cardiovascular disease and cognitive impairment and is a determining factor in overall morbidity and mortality. The continued presence of modifiable risk factors, such as hypertension, diabetes
Mikaelle Costa Correia, Matheus Henrique de Jesus Lima, Amanda Rodrigues Bitencourt, Aline Rosa de Castro Carneiro, Rogério Orlow de Oliveira, Sayuri Inuzuka, Adriana Camargo Oliveira, Marco Túlio Araújo Pedatella, Polyana Vulcano de Toledo Piza, Gustavo Frigieri, Weimar Kunz Sebba Barroso   +10 more
doaj   +1 more source