Results 71 to 80 of about 4,995,617 (183)

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Targeted delivery for treatments for restenosis and vein graft disease [PDF]

, 2012
Surgery to restore blood flow in arteries blocked by atherosclerotic plaque is a common treatment in cardiovascular disease. Longtermcomplications of surgical treatment are vein graft disease and restenosis, a renarrowing of the blood vessel after ...
Thomas, Anita C
core   +1 more source

Acute Effects of Smoking and Vaping on Markers of Vascular Function via Quantitative MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background E‐cigarettes contribute to endothelial dysfunction, a known cause of systemic atherosclerotic disease that cannot be adequately characterized by a single physiological parameter measured at a single vascular bed. Purpose/Hypothesis Quantify and compare acute effects of smoking or vaping with tobacco cigarettes (t‐cigs), nicotinized ...
Marianne Nabbout, Mahdie Hosseini, Harris Quach, Michael C. Langham, Alessandra S. Caporale, Wensheng Guo, Kathryn Jaroszynski, Frank T. Leone, Andrew A. Strasser, Felix W. Wehrli   +9 more
wiley   +1 more source

Perfusion imaging and recurrent cerebrovascular events in intracranial atherosclerotic disease or carotid occlusion

, 2018
Background Large vessel disease stroke subtype carries the highest risk of early recurrent stroke. In this study we aim to look at the association between impaired perfusion and early stroke recurrence in patients with intracranial atherosclerotic ...
Joshua Z Willey, Shyam Prabhakaran, Mahesh V Jayaraman, Mitchell SV Elkind, Bradford Thompson, Karen L Furie, Morgan Hemendinger, Andrew D Chang, Shadi Yaghi, Daniel C Sacchetti, Pooja Khatri, Ryan A McTaggart, Sara K Rostanski, Shawna M Cutting, Matthew S Siket, Tina Burton, Randolph S Marshall, Brian Mac Grory   +17 more
core   +1 more source

Symptomatic and asymptomatic intracranial atherosclerotic stenosis: 3 years' prospective study. [PDF]

, 2020
BACKGROUND Intracranial stenoses can cause TIA/ischaemic stroke. The purpose of this study was to assess vascular risk factors, clinical and imaging findings and outcome in Caucasians with intracranial stenosis under best prevention management ...
Arnold, Marcel, Heldner, Mirjam R., Wiest, R., Gralla, J., Wiest, Roland, Hsieh, Kety, Mattle, Heinrich P., Mattle, H.P., Fischer, Urs, Gralla, Jan, Kellner, Frauke, Kellner-Weldon, F., Kaesmacher, J., Kaesmacher, Johannes, Jung, S., Galimanis, A., Fischer, U., Michel, Patrik, Jung, Simon, Yan, X., Arnold, M., Heldner, M.R., Hsieh-Meister, K., Galimanis, Aikaterini, El-Koussy, M., Yan, Xin, El-Koussy, Marwan, Michel, P.   +27 more
core   +2 more sources

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Intracranial Stenting: Is It Still an Option for Treatment of Patients With Intracranial Atherosclerosis?

Frontiers in Neurology, 2019
Intracranial atherosclerotic disease (ICAD) is considered a major cause of recurrent cerebrovascular events. ICAD continues to be a disease without an effective method of reducing the risk of recurrent stroke and death, even with aggressive, highly ...
Ahmed Abualhasan, Ahmed Abualhasan, Foad Abd-Allah, Guglielmo Pero, Khaled Sobh, Ossama Mansour, Omar El-Serafy, Edoardo Boccardi   +7 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Ethnic Differences in Outcomes of Endovascular Thrombectomy in New Zealand

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Stroke is a leading cause of morbidity and mortality in New Zealand, with ethnic disparities known to exist. Endovascular thrombectomy (EVT) has proven efficacy in reducing or preventing disability for stroke patients, but little is known about ethnic differences in functional outcomes following EVT in New Zealand.
Jaron Huang, Alicia Tyson, Muthu Muthappan, Annemarei Ranta   +3 more
wiley   +1 more source