Results 81 to 90 of about 17,534 (188)

Intracranial atherosclerotic disease

Stroke, 2020
Craig Hacking, Rohit Sharma, Giorgio Maria Agazzi   +2 more
openaire   +3 more sources

Cerebrovascular flow‐mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations

Experimental Physiology, EarlyView.
Abstract Arterial shear‐mediated vasodilation is a well‐established measure of endothelial function and serves as a critical biomarker for cardiovascular disease risk. Endothelial function can be measured using a variety of experimental methodologies; however, the most widely adopted technique is ultrasound‐based flow‐mediated dilation (FMD), in which ...
Yi Zhen Bao, Tabitha V. Craig, Jenna C. McCrone, Kurt J. Smith, Michael M. Tymko   +4 more
wiley   +1 more source

Vascular Abnormalities in Hypermobile Ehlers–Danlos Syndrome: A Retrospective Cohort Study

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2080-2087, September 2026.
ABSTRACT Hypermobile Ehlers–Danlos syndrome (hEDS), while generally free from severe vascular complications, may occasionally present with cardiac and vascular abnormalities that warrant specific investigation. While studies have been conducted on the prevalence of cardiac involvement, none have focused on vascular aspects. This retrospective study was
Thomas Gehin, Malika Foy, Robert Carlier, Valentin Renault, Karelle Benistan   +4 more
wiley   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, Volume 100, Issue 3, Page 458-476, September 2026.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Panvascular Changes Under Intensive Medical Therapy in Intracranial Atherosclerotic Steno‐Occlusive Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While intensive medical therapy improves culprit plaque characteristics in intracranial atherosclerotic steno‐occlusive disease, its broader effects on the intracranial arterial tree, venous pathways, and meningeal lymphatic system remain ...
WeiZhuang Yuan, Ming‐Li Li, Yue‐Lun Zhang, Zhongrui Yan, Wei‐Hai Xu   +4 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

The History of the Discovery of Vitamin K

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Vitamin K was discovered during the 1930s when a strange haemorrhagic disorder was observed in chickens fed a cholesterol‐free diet. A fat‐soluble agent, present in green leafy vegetables and hog liver, was able to restore haemostasis in the chickens.
Hanna Nørgaard Tuxen, Laila Zwisler, Allan Linneberg   +2 more
wiley   +1 more source

Arterial brain calcium (ABC) volume - A novel radiological marker of atherosclerotic risk and future stroke risk on non-contrast CT

Journal of Stroke and Cerebrovascular Diseases
Background and Purpose: Coronary calcium is a well-recognized marker of atherosclerotic risk. While intracranial carotid artery calcification has received some attention, calcific disease in other intracranial arteries is not well studied.
Arun Kathuveetil, MD DM, Diana Kim, MD, Mankirat Bhogal, MD, Ali Babwani, MD, Mao Ding, Babawale Arabambi, Sucharita Ray, MD DM, Ibrahim Alhabli, MD, Aravind Ganesh, MD, D Phil (Oxon), FRCPC   +8 more
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, Volume 13, Issue 16, 18 August 2026.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Cross‐ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Genome‐wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer's disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low.
Meri Okorie, Caroline Jonson, Alexis P. Oddi, Patricia A. Castruita, Brian Fulton‐Howard, Kristine Yaffe, Jennifer S. Yokoyama, Chinedu Udeh‐Momoh, Shea J. Andrews, for the Alzheimer's Disease Sequencing Project and the Healthy Aging Brain Study—Health Disparities   +9 more
wiley   +1 more source