Results 91 to 100 of about 136,147 (343)

Cerebral haemodynamics during experimental intracranial hypertension. [PDF]

, 2016
Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood.
Ainslie, Philip N, Cardim, Danilo, Czosnyka, Marek, Donnelly, Joseph, Harland, Spencer, Liu, Xiuyun, Robba, Chiara, Smielewski, Peter, Varsos, Georgios V   +8 more
core   +2 more sources

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Ischemic stroke in a patient with EGFR‐mutated non–small‐cell lung cancer after treatment with ramucirumab

Thoracic Cancer, Volume 13, Issue 23, Page 3412-3414, December 2022., 2022
A case of a non–small‐cell lung cancer patient harboring epidermal growth factor receptor mutation with multiple brain metastasis experienced a new ischemic stroke after treatment with ramucirumab. Abstract Vascular endothelial growth factor (VEGF) inhibitors have been widely investigated in the last 10 years, with particular attention paid to their ...
Guo‐Yu Chen, Wen‐Chien Cheng, Chih‐Yen Tu   +2 more
wiley   +1 more source

A pathway-based network analysis of hypertension-related genes [PDF]

Physica A 447 (2016) 569--570, 2016
Complex network approach has become an effective way to describe interrelationships among large amounts of biological data, which is especially useful in finding core functions and global behavior of biological systems. Hypertension is a complex disease caused by many reasons including genetic, physiological, psychological and even social factors.
arxiv   +1 more source

Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension [PDF]

, 2002
Journal ArticleWe quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure.
Digre, Kathleen B., Yemelyanov, Alexander   +1 more
core  

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study

Acta Anaesthesiologica Scandinavica, Volume 67, Issue 1, Page 57-65, January 2023., 2023
Abstract Background Oxygen supply to the brain is of special importance during intracranial surgery because it may be compromised by intracranial pathology. A high arterial blood pressure (mean arterial pressure above 80 mmHg) and a high arterial oxygen tension (PaO2 above 12 kPa) is therefore often targeted in these patients, when for example ...
Sofie S. Pedersen, Christian S. Meyhoff, Markus Harboe Olsen, Zara R. Stisen, Anton Lund, Kirsten Møller, Jane Skjøth‐Rasmussen, Finn B. Moltke, Martin Kryspin Sørensen   +8 more
wiley   +1 more source

Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading to Cascade Diagnosis for Multiple Generations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. This clinical report highlights the intrafamilial variability that can exist with this specific variant. The proband is a 4‐year‐old boy who initially presented with concern for seizures.
Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang   +3 more
wiley   +1 more source

Effect of Hyperosmolar Solutions on Cerebral Oxygenation and Metabolism

Общая реаниматология, 2008
Objective: to assess the time course of changes in the parameters of cerebral oxygenation and metabolism in the correction of intracranial hypertension with hyperosmolar solutions. Material and methods.
S. S. Petrikov, V. V. Krylov, A. A. Solodov, Yu. V. Titova, Kh. T. Guseinova, L. T. Khamidova   +5 more
doaj   +1 more source

What went wrong? The flawed concept of cerebrospinal venous insufficiency [PDF]

, 2013
In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis (MS), coining the term of chronic cerebrospinal venous insufficiency ('CCSVI'). The diagnosis of 'CCSVI' is
Al-Omari MH, Alikhani K, Bartomolei I, Batson OV, Baumgartner RW, Benabid AL, Doepp F, Eckenhoff JE, Hempel KJ, Hojnacki D, Kipshidze N, Kostecki J, Lang J, Lang J, Ludyga T, Malagoni AM, Masuhr F, Mayer C, Nicolaides AB, Oberwahrenbrock T, Odake G, Oktar SO, Salvi F   +22 more
core   +2 more sources