Interdisciplinary Medicine, EarlyView.Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi +13 more
wiley +1 more source
Increased intracranial pressure in severe traumatic axonal injury patients - A retrospective single-center study. [PDF]
Brain SpineWesterberg G +4 more
europepmc +1 more source
Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng +9 more
wiley +1 more source
Positive end-expiratory pressure increases intracranial pressure but does not affect PRx, regardless of body position, in a porcine ARDS model. [PDF]
Front PhysiolHammervold R +6 more
europepmc +1 more source
The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators
Journal of Hospital Medicine, EarlyView.Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield +3 more
wiley +1 more source
Management of intracranial hypertension with and without invasive intracranial pressure monitoring. [PDF]
World J Crit Care MedBianchini L +3 more
europepmc +1 more source
Barriers to nutrition following neurosurgery: A descriptive cohort study
Journal of Parenteral and Enteral Nutrition, EarlyView.Abstract Background Neurological trauma results in a state of hypermetabolism. Existing literature has explored barriers to adequate nutrition following traumatic brain injury. Despite clinical similarities, it remains unclear whether similar nutritional barriers are faced following both planned and emergency neurosurgical procedures.
Dale Palmer, Melissa Zhou, Suzie Ferrie
wiley +1 more source
A Novel Slit Lamp‐Based System for 3D Ultrasound of the Eye
Journal of Ultrasound in Medicine, EarlyView.Objectives This study aims to develop and evaluate a novel slit‐lamp‐based system to acquire 3‐dimensional (3D) ultrasound volumes using conventional ultrasound probes. Methods A slit‐lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2‐dimensional scans ...
Claire E. Malley +9 more
wiley +1 more source
Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review
The Laryngoscope, EarlyView.PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian +4 more
wiley +1 more source
Personalized Treatment of Patients With Multiple Sclerosis: A Case Report and Literature Review
Medicine Bulletin, EarlyView.ABSTRACT Managing multiple sclerosis (MS) with a highly active disease course presents significant challenges, particularly regarding the timing of therapeutic escalation and the preservation of brain volume. We present a personalized management strategy for a 36‐year‐old male with relapsing‐remitting MS (RRMS) who experienced initial misdiagnosis ...
Fengjun Wang +3 more
wiley +1 more source