Results 51 to 60 of about 88,298 (320)
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Conservative management of low back pain [PDF]
, 2001 Back pain is prevalent worldwide, but back pain disability has reached epidemic proportions in many industrialised societies. Few patients have serious medical pathology or direct neurological involvement requiring surgery.
De Souza, LH, Frank, AO
core
Epilepsia Open, EarlyView.Abstract Objective To investigate the efficacy and tolerability of perampanel (PER) on Dravet syndrome in China by a prospective real‐world study. Methods We prospectively enrolled children with Dravet syndrome from the neurology clinic of Shenzhen Children's Hospital from September 2020 to October 2021.
Han Wang +9 more
wiley +1 more source
A 92-Year-Old Man with Abdominal Pain Following Intractable Vomiting; a Photo Quiz
Archives of Academic Emergency Medicine, 2019 A 92-year-old man with hypertension, chronic obstructive pulmonary disease (COPD), peptic ulcer disease and dementia presented to the emergency department with a 2-day history of abdominal pain in the left upper quadrant, distention, dry cough and ...
Chin-Chu Wu, Aming Chor-Ming Lin
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Objective This study aimed to evaluate the efficacy and safety of adjunctive, highly purified Cannabidiol (Epidiolex®) in individuals with drug‐resistant epilepsy (DRE) due to genetically determined typical Rett Syndrome (RTT) and CDKL5 Deficiency Disorder (CDD). Methods We recruited subjects with genetically confirmed typical RTT and CDD with
Aglaia Vignoli +22 more
wiley +1 more source
Future in Educational Research, EarlyView.ABSTRACT This conceptual essay, grounded in a close reading of Plato's Theaetetus, argues that before educators can effectively operationalise critical thinking as the rigorous evaluation ('stress‐testing') of competing knowledge claims, university students must first understand foundational epistemological principles rooted in Plato's tripartite ...
Gerry Dunne
wiley +1 more source
Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. [PDF]
, 2019 The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Gutierrez, Lorenzo +9 more
core
Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]
, 2019 The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant +40 more
core +1 more source
The Management of Head and Neck Lymphoedema: A 2025 Systematic Review
Head &Neck, EarlyView.ABSTRACT Background Head and Neck Lymphoedema (HNL) is debilitating to many domains of patients' structure and function, yet it is the most poorly researched form of lymphoedema. This is due to the variety of signs and symptoms experienced by HNL patients, and this makes it difficult to formulate standardized staging classifications and treatment ...
Rohan Rajaram +4 more
wiley +1 more source