Results 71 to 80 of about 37,015 (229)
Topics in Cognitive Science, EarlyView., 2023 Abstract Over the past three decades, Van Gelder's dynamical hypothesis has been instrumental in reconceptualizing the ways in which perception‐action‐cognition unfolds over time and in context. Here, I examine how the dynamical approach has enriched the theoretical understanding of social dynamics within cognitive science, with a particular focus on ...
Alexandra Paxton
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Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
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Brain SciencesBackground: Spinal cord stimulation (SCS) is applied for managing chronic intractable pain, but the factors predicting its effectiveness have not been extensively researched.
Yongjae Yoo +5 more
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Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Infrared Therapy for Chronic Low Back Pain: A Randomized, Controlled Trial
Pain Research and Management, 2006 OBJECTIVE: The objective of the present study was to assess the degree of pain relief obtained by applying infrared (IR) energy to the low back in patients with chronic, intractable low back pain.
George D Gale, Peter J Rothbart, Ye Li
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British Journal of Pharmacology, EarlyView.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Erector spinae plane block for intractable, nonsurgical abdominal pain: a scoping review [PDF]
Clinical and Experimental Emergency MedicineAbdominal pain is one of the most common presenting chief complaints in the emergency department. Erector spinae plane block (ESPB) is an ultrasound-guided nerve block with proven effectiveness in treating visceral and somatic abdominal pain. Despite the
Ashley Meyer +8 more
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Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Pain Research and Management, 2000 Intractable pain demands the attention of both the patient and the physician. However, modern science and medicine cannot and should not promise the abolition of pain and suffering.
John D Loeser
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