Results 51 to 60 of about 16,684 (214)

Polymer multilayer tattooing for enhanced DNA vaccination [PDF]

, 2012
DNA vaccines have many potential benefits but have failed to generate robust immune responses in humans. Recently, methods such as in vivo electroporation have demonstrated improved performance, but an optimal strategy for safe, reproducible, and pain ...
Barouch, Dan H., DeMuth, Peter Charles, Hammond, Paula T., Huang, Bonnie, Irvine, Darrell J., Kramer, Joshua A., Miller, Andrew D., Min, Younjin   +7 more
core   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Near-Infrared Laser Adjuvant for Influenza Vaccine [PDF]

, 2013
Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally.
Brauns, Timothy, Bronson, Roderick, Chen, Tao, Collette, Brian, Dover, Jeffrey, Edelblute, Beth, Edington, Laurel, Forbes, Benjamin, Gelfand, Jeffrey, Goudie, Calum, Hibert, Mathew L., Kashiwagi, Satoshi, Leblanc, Pierre, Lee, Eugene L. Q., Nezivar, Jean, Poznansky, Mark C., Suematsu, Makoto, Trussler, James, Tsukada, Kosuke, Whicher, Laura, Yang, Yuan, Yuan, Jianping   +21 more
core   +6 more sources

Evaluation of Behavioral Aspects after Intradermal and Intramuscular Vaccine Application in Suckling Piglets

Agriculture, 2020
The aim of this study was to analyse the behavioral aspects of suckling piglets after an intradermal vaccination method in comparison to an intramuscular vaccination applied on the seventh day of life.
Manuel Göller, Nicole Kemper, Michaela Fels   +2 more
doaj   +1 more source

Percutaneous sentinel node removal using a vacuum-assisted needle biopsy in women with breast cancer:a feasibility and acceptability study [PDF]

, 2019
AIMS: To assess the feasibility and acceptability of large-gauge percutaneous removal of the axillary sentinel lymph node (SLN) using dual gamma probe and ultrasound guidance.MATERIALS AND METHODS: Technetium nanocolloid was administered the day before ...
Brown, D., Evans, A., Macaskill, E. J., Pitsinis, V., Purdie, C., Thompson, A., Warwick, V., Whelehan, P.   +7 more
core   +2 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Investigating the Mechanisms of Intradermal Injection for Easier “Skin Booster” Treatment: A Fluid Mechanics Approach to Determine Optimal Delivery Method

Plastic and Reconstructive Surgery, Global Open
Background:. The use of “skin boosters” for rejuvenating aged skin is widely used. However, the accurate injection of the skin booster into the dermal layer remains a challenge due to the density of the dermis.
Seung Min Oh, MD, Yongkoo Lee, PhD, Jae Hyuk Lee, DS, Myungjune Oh, MD   +3 more
doaj   +1 more source

Spinal neurons that contain gastrin-releasing peptide seldom express Fos or phosphorylate extracellular signal-regulated kinases in response to intradermal chloroquine [PDF]

, 2016
Background: Gastrin-releasing peptide (GRP) is thought to play a role in the itch evoked by intradermal injection of chloroquine. Although some early studies suggested that GRP was expressed in pruriceptive primary afferents, it is now thought that GRP ...
Bell, Andrew M., Gutierrez-Mecinas, Maria, Polgár, Erika, Todd, Andrew J.   +3 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by Paclitaxel [PDF]

, 2011
Peripheral neuropathy is a major side effect following treatment with the cancer chemotherapeutic drug paclitaxel. Whether paclitaxel-induced peripheral neuropathy is secondary to altered function of small diameter sensory neurons remains controversial ...
Basile, DP., Cummins, TR., Gracias, NG., Iqbal, T., Kelley, Mark R., Vasko, Michael R.   +5 more
core   +1 more source