Results 111 to 120 of about 45,883 (225)

Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system

open access: yesHistopathology, Volume 88, Issue 7, Page 1295-1314, June 2026.
Changes and new entities in the 6th edition WCT of the digestive system, including structural, molecular, and diagnostic updates to standardize terminology and improve clinical relevance. Epithelial tumours are organized by site; neuroendocrine, mesenchymal and haematolymphoid tumours have dedicated chapters, with refined grading, redefined ...
Mark J Arends   +48 more
wiley   +1 more source

Tall Cell Carcinoma of the Breast With Reverse Polarity: Expanding the Molecular Spectrum With IDH1 R132 Mutation

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping histopathological features with papillary thyroid carcinoma and a characteristic immunohistochemical (IHC) and molecular profile.
Abhisek Jha   +6 more
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal   +6 more
wiley   +1 more source

Boost Approaches in Patients Undergoing Postoperative Radiotherapy

open access: yesJournal of Surgical Oncology, Volume 133, Issue 6, Page 773-784, May 2026.
ABSTRACT The use of breast conservation surgery for early‐stage breast cancer is common, and adjuvant radiotherapy is often recommended to reduce the risk of ipsilateral breast tumor recurrence. Historical trials have used sequential boost techniques with favorable outcomes with reduction in local recurrence and acceptable cosmetic outcomes.
Abigail Pepin   +5 more
wiley   +1 more source

Cholangiolocellular Component Predicts a Biologically Distinct Subgroup of Mass‐Forming Intrahepatic Cholangiocarcinoma

open access: yesCancer Science, Volume 117, Issue 5, Page 1510-1523, May 2026.
We identified two distinct molecular subgroups of mass‐forming intrahepatic cholangiocarcinoma (MF‐iCCA) based on the presence of a histological cholangiolocellular carcinoma (CLC) component. The CLC‐related molecular subgroup showed better prognosis and highly angiogenic features, as confirmed by both genetic analysis and morphological observation ...
Naoto Kubota   +9 more
wiley   +1 more source

Context-aware stacked convolutional neural networks for classification of breast carcinomas in whole-slide histopathology images

open access: yes, 2017
Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area.
Balkenhol, Maschenka   +8 more
core   +1 more source

Diagnostic and Prognostic Values of Bile Biomarkers for Malignant Biliary Stenosis

open access: yesLiver International, Volume 46, Issue 5, May 2026.
ABSTRACT Introduction Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour‐related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy.
E. Gigante   +9 more
wiley   +1 more source

RAB family gene expression in breast cancer cells under influence of paclitaxel [PDF]

open access: yes, 2011
The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with
Andrzej Wilkolaski   +3 more
core   +1 more source

Intraductal chemotherapy for triple-negative breast cancer: a pathway to minimally invasive clinical treatment

open access: yesBMC Cancer
Triple-negative breast cancer (TNBC) is traditionally treated with systemic chemotherapy, often resulting in significant off-target toxicity. In this study, we assess the efficacy of intraductal chemotherapeutic delivery, aimed at reducing systemic side ...
Xinhong Wu   +7 more
doaj   +1 more source

PPAR-alpha: a novel target in pancreatic cancer [PDF]

open access: yes, 2015
Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
core   +1 more source

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