Results 131 to 140 of about 51,227 (230)

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Endometrioid Intraepithelial Neoplasia in the Secretory Phase: Morphologic and Biomarker Diagnostic Features in a Common, Overlooked Setting. [PDF]

Am J Surg Pathol
Means AM, Lucas E, Zhang S, Rivera-Colon G, Niu S, Chen L, Zheng W, Carrick KS, Gwin K, Grubman J, Chen H, Castrillon DH.   +11 more
europepmc   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Diagnostic Utility of Acetic Acid-induced Acetowhite Change in Suspected Penile Intraepithelial Neoplasia. [PDF]

Cureus
Haider JM, Kamran S.
europepmc   +1 more source

The impact of physiological oxidants on triggering amyloid formation of the cell cycle regulator protein p16INK4A

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The tumor suppressor protein p16INK4a plays a key role in cell cycle control and is frequently inactivated in human cancers. We previously discovered that oxidation of its single cysteine residue induces a structural transition from the functional monomeric form into inactive amyloid fibrils.
Briana R. Smith, Nicholas J. Magon, Aakriti Sethi, Shelby G. Gray, Sarah G. Heath, Vanessa K. Morris, Christoph Göbl   +6 more
wiley   +1 more source

Prognostic impact of pancreatic intraepithelial neoplasia at the resection margin in pancreas cancer. [PDF]

BMC Surg
Shiihara M, Shimoda M, Miyamoto R, Morishita Y, Kou K, Suzuki S.   +5 more
europepmc   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Early effects of HPV vaccination on high-grade cervical intraepithelial neoplasia in Brazil: Evidence from outpatient data. [PDF]

Hum Vaccin Immunother
Bierrenbach AL, Pungartnik PC, Gonçalves Queijo R, Rego JG, Parellada CI.   +4 more
europepmc   +1 more source

Outcome of vaginal intraepithelial neoplasia following hysterectomy for cervical intraepithelial neoplasia

Journal of Obstetrics and Gynaecology, 2006
I, Babarinsa, J, Mathew, C, Wilson, A, Oladipo   +3 more
openaire   +2 more sources

Gynaecologists' Views and Acceptability of Active Surveillance for Women Diagnosed With Cervical Intraepithelial Neoplasia 2: A Qualitative Study

Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 66, Issue 4, August 2026.
ABSTRACT Background Persistent oncogenic HPV infection can cause cervical epithelial changes leading to premalignant lesions such as CIN2. Active surveillance, a conservative option, reduces exposure to excisional risks while allowing timely treatment when needed. However, little is known about clinicians' perspectives, acceptability, and experience of
Dan Luo, Ashleigh R. Sharman, Deborah Bateson, Megan Smith, Kirsten I. Black, Katy Bell, Kirsten J. McCaffery, Rachael H. Dodd   +7 more
wiley   +1 more source