Results 81 to 90 of about 51,227 (230)

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, EarlyView.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Efficacy and Safety of Anal High‐Grade Squamous Intraepithelial Lesion Treatment Modalities: A Systematic Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background There is compelling evidence that treating high‐grade squamous intraepithelial lesions (HSIL), the anal squamous cell cancer (ASCC) precursor, reduces the risk of developing ASCC. Using high‐resolution anoscopy (HRA), surgical excision, ablative and topical therapies are widely used to treat HSIL.
Matthew Joseph Marino, Sophie Jones, Nicholas Reid Caldwell, Catherine Cartwright, Benedict Blacket, Richard Clive Turner   +5 more
wiley   +1 more source

Human papillomavirus persistence and clearance in women living with HIV: A five‐year retrospective analysis from an Italian university center

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In women living with HIV, HPV clearance occurred after a mean of approximately 2 years under antiretroviral therapy. Baseline positivity for the high‐risk HPV pool was associated with delayed clearance, suggesting that HPV genotype may influence viral persistence more than immunovirological status in clinically stable patients.
Annunziata Carlea, Dario Colacurci, Giorgia D'Apice, Laura Letizia Mazzarelli, Massimiliano Pellicano, Luigi Falco, Ginevra Sepe, Oriana Imperatore, Giuseppe Maria Maruotti, Maurizio Guida, Laura Sarno   +10 more
wiley   +1 more source

Loss to follow‐up in patients diagnosed with or treated for low‐ and high‐grade squamous intraepithelial lesions: A comparison of general practitioner‐ and gynecologist‐led surveillance

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Follow‐up by general practitioners after LSIL or treated HSIL was associated with higher loss to follow‐up rates compared with gynecologist‐led care. Loss to follow‐up was 38.1% versus 16.6% for LSIL at 12 months and 44.3% versus 24.1% for treated HSIL at 24 months.
Lieke van de Kam, Albert Siebers, Ruud Bekkers, Dennis van Hamont, Jurgen Piek   +4 more
wiley   +1 more source

Use of topical imiquimod in the treatment of VIN: a case report and review of the literature

International Journal of Women's Dermatology, 2016
Vulvar intraepithelial neoplasia (VIN) is a premalignant disease of the vulvar squamous epithelium. Standard treatment for VIN lesions is surgical excision.
Chelsea Grimes, BS, MS, Cheri Cunningham, BS, Michael Lee, MD, Andrea Murina, MD   +3 more
doaj   +1 more source

Active surveillance of cervical intraepithelial neoplasia and adverse pregnancy outcomes: A register‐based cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Active surveillance for cervical intraepithelial neoplasia grade 2 is not associated with increased risks of adverse pregnancy outcomes compared to large loop excision of the transformation zone. Abstract Introduction Previous studies have suggested that human papillomavirus (HPV) and HPV‐related disease may be associated with increased risk of adverse
Kirstine Kold Katholm, Lotte Krog Eriksen, Kathrine Dyhr Lycke, Ninna Lund Larsen, Iben Sundtoft, Tina Hovgaard Randrup, Anne Hammer   +6 more
wiley   +1 more source

Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis

Radiology and Oncology
The aim of the present study was to assess a diagnostic potential of stem cell markers NANOG and SOX2 for classifying cervical squamous intraepithelial lesions (SILs)/cervical intraepithelial neoplasia (CIN).
Koren Miha, Zlajpah Margareta, Poljak Mario, Komlos Kristina Fujs, Flezar Margareta Strojan   +4 more
doaj   +1 more source

Women's experiences, responses, and coping strategies when testing positive for human papillomavirus in cervical cancer screening: A qualitative study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study demonstrates that women's experiences following an hrHPV diagnosis within cervical screening extend beyond individual reactions to medical information, encompassing complex psychological, social, and cultural dimensions that influence how women interpret and manage the diagnosis.
Joan Hansen, Beth J. Maclin, Birgitte Folmann, Jane Ege Møller, Ane Kersti Skaarup Knudsen, Vibeke Raaby, Anne Hammer   +6 more
wiley   +1 more source

Silicon dioxide vaginal gel and short‐term high‐risk human papillomavirus DNA detectability: A randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In an independent randomized trial of 242 women with PCR‐confirmed hrHPV infection, 3 months of silicon dioxide‐based vaginal gel did not improve hrHPV DNA non‐detectability compared with observation alone (18% vs. 21%). Patient‐reported adverse events were more frequent with gel (32% vs. 2%), and overall patient satisfaction was lower.
Julia M. Hecken, Clemens B. Tempfer, Katrin Klaus, Jan Scheich, Günther A. Rezniczek   +4 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source