Results 91 to 100 of about 130,124 (257)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

An unusual presentation of corneal intraepithelial neoplasia [PDF]

, 2020
Introduction: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion.
Celdrán Vivancos, Diego Asensio, Garrido Ceca, Guadalupe, Marticorena-Álvarez, Paula   +2 more
core  

MAVARIC - a comparison of automation-assisted and manual cervical screening: a randomised controlled trial. [PDF]

, 2011
OBJECTIVES: The principal objective was to compare automation-assisted reading of cervical cytology with manual reading using the histological end point of cervical intraepithelial neoplasia grade II (CIN2) or worse (CIN2+). Secondary objectives included
G Dunn, S Moss, MAVARIC Trial Study Group, R Blanks, Sadique, A, Sadique, Z, Kitchener, HC, Dunn, G, A Gray, Moss, S, M Desai, Cubie, H, Blanks, R, R Legood, Legood, R, Desai, M, H Cubie, Desia, M, Z Sadique, Gray, A, HC Kitchener   +20 more
core   +1 more source

Apo10 and TKTL1 as novel liquid biopsy biomarkers for early detection of gastrointestinal malignancies

VIEW, EarlyView.
(A) Overview of the study population and schematic illustration showing tumor‐derived apoptotic and metabolic biomarkers, Apo10 and TKTL1, being phagocytosed by circulating monocytes and subsequently detected in peripheral blood. (B) Illustration of the epitope detection in monocytes (EDIM) strategy, using a flow‐cytometric gating approach based on ...
Zhiying Mao, Qiyu Huang, Juan Xiao, Ziyu Liu, Xinyan Zou, Yuying Liu, Lizhi Liu, Musheng Zeng, Chuanbo Xie   +8 more
wiley   +1 more source

Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands [PDF]

, 2019
OBJECTIVE: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.
Horenblas, Simon, Hoekstra, Robert J., Evelien J Trip, Fybo JW ten Kate, Robert J Hoekstra, Simon Horenblas, Trip, Evelien J., Lock, M. T. W. Tycho, ten Kate, Fybo J. W., MTW Tycho Lock   +9 more
core   +1 more source

A Prediction Model for the Differential Diagnosis of Bowen's Disease and Bowenoid Actinic Keratosis

The Journal of Dermatology, EarlyView.
ABSTRACT Bowen's disease and bowenoid actinic keratosis share overlapping clinical and histopathological features, and there is no clear consensus regarding their differential diagnosis. This study aimed to identify clinicopathological differences between the two diseases and to develop a diagnostic prediction model in a Korean population.
Byeonghyun Joo, Hyungrye Noh, Jin Ho Kim, Jong Hee Lee, Dongyoun Lee, Jun Young Kim, Jihye Park   +6 more
wiley   +1 more source

[Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV]. [PDF]

, 2011
HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), the precursor lesions for cervical cancer. This study estimated and compared the performance of cytology and hybrid capture II in screening for ...
Andrea Cytryn, Grinsztejn, Beatriz Gilda Jegerhorn, Russomano, Fábio Bastos, Letícia Martins Raposo, Cytryn, Andrea, Velasque, Luciane de Souza, Velasque, Luciane, Raposo, Let??cia Martins, Luz, Paula Mendes, Veloso, Valdil??a Gon??alves, Luciane Velasque, Santos, Valdiléa Gonçalves Veloso dos, Brasil, Pedro EAA, Pedro E. A. A. Brasil, Friedman, Ruth Khalili, Veloso, Valdiléa Gonçalves, Russomano, F??bio Bastos, Angela Cristina Vasconcelos de Andrade, Raposo, Letícia Martins, Vanni, Tazio, Russomano, Fabio, Beatriz Grinsztejn, Cytryn, Andr??a, Struchiner, Claudio José, Ruth Khalili Friedman, Andrade, Angela Cristina Vasconcelos de, Valdiléa Gonçalves Veloso, Claudio José Struchiner, Paula Mendes Luz, Grinsztejn, Beatriz, Fabio Russomano, Tazio Vanni, Brasil, Pedro E. A. A., Struchiner, Claudio Jos??   +33 more
core   +1 more source

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source

Prognostic Value of KI6 Biomarker to Predict Short Term Prognosis of Low Grade Cervical Intraepithelial Neoplasia in Human Papilloma Virus Negative and Positive Patients

Middle East Journal of Cancer, 2019
Background: Cervical cancer is the most common gynecologic cancer in developing countries. Although this malignancy is preventable, problems exist with screening this cancer. Numerous studies have researched immunohistochemistry methods, such as the KI-
Leila Mousavi Seresht, Noorieh Sharifi, Mona Najafi, Helena Azimi, Nooshin Babapour, Zohreh Yousefi, Nazanin Beheshtian, Yasaman Nikooiyan   +7 more
doaj  

Cervical intraepithelial neoplasia grade 2 across continents.

, 2014
Cervical intraepithelial neoplasia grade 2 across continents.
Apple C. M. Yeung (626923), Martin C. S. Wong (288769), Wendy C. S. Ho (630581), Josette S. Y. Chor (630582), Mamie Hui (630583), Paul K. S. Chan (271343), Martin C. W. Chan (341911)   +6 more
core   +1 more source