Results 31 to 40 of about 59,257 (200)

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Translational Oncology, 2021
Neoplasia of the cervix represents one of the most common cancers in women. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients.
Yenddy N. Carrero, Diana E. Callejas, Jesús A. Mosquera   +2 more
doaj   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

Functional Advantage of Central Pancreatectomy Over Distal Pancreatectomy for Benign or Low‐Grade Malignant Tumors: A Comparative Analysis Based on 75‐g Oral Glucose Tolerance Test

Annals of Gastroenterological Surgery, EarlyView.
Central pancreatectomy (CP) better preserves postoperative pancreatic endocrine function than distal pancreatectomy for benign or low‐grade malignant tumors. The 75‐g oral glucose tolerance test demonstrated that CP maintained insulin secretion and glucose tolerance, highlighting its clinical advantage as a function‐preserving procedure.
Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Yuki Okuda, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto   +9 more
wiley   +1 more source

Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia

International Journal of Hepatology, 2014
Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar/perihilar and extrahepatic cholangiocarcinoma. BilIN represents the process of multistep cholangiocarcinogenesis and is the biliary counterpart of pancreatic intraepithelial ...
Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma   +3 more
doaj   +1 more source

Individual risk of cervical intraepithelial neoplasia progression in patients with chronic cervicitis

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016
We proposed predictive method of cervical intraepithelial neoplasia progression in women with chronic cervicitis, it is favorable one in routine clinical practice.
O. M. Bokach, A. V. Tishkov
doaj   +1 more source

Edge Information‐Augmented Auxiliary Diagnosis Method for Cervical Cancer in Medical Decision‐Making Systems

Advanced Intelligent Systems, EarlyView.
To address the problems of insufficient utilization of multiscale features and inefficient feature sharing between tasks in the model, this study proposes an edge‐enhanced intelligent cervical cancer screening method that achieves feature reuse and improves efficiency by jointly optimizing nucleolus segmentation and lesion classification.
Li Wen, Xiaoqing Zhang, Tingyi Dai, Fangfang Gou, Jia Wu   +4 more
wiley   +1 more source

Results from phase III clinical trials with radachlorine for photodynamic therapy of pre-cancer and early cancer of cervix

Biomedical Photonics, 2015
The results of clinical study for efficacy of photodynamic therapy (PDT) with radachlorine in patients with pre-cancer and cancer of cervix are represented.
E. V. Filonenko, L. G. Serova, V. I. Ivanova-Radkevich   +2 more
doaj   +3 more sources

Cervical intraepithelial neoplasia. Clinical analysis

Клинический разбор в общей медицине, 2023
Cervical intraepithelial neoplasia (CIN) is the most relevant topic in cervicology due to the risk of progression to cervical cancer and its rejuvenation.
Tatiana V. Klinyshkova , Natalia B. Frolova   +1 more
doaj   +1 more source

Insights into organelle forming RNAs: Diversity, functions and future perspectives

Animal Models and Experimental Medicine, EarlyView.
RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley   +1 more source