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Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase

Angewandte Chemie, 2021
AbstractThe reliable design and prediction of enzyme promiscuity to access transformations not observed in nature remains a long‐standing challenge. Herein, we present the first example of an intramolecular stereoselective Stetter reaction catalyzed by benzaldehyde lyase, guided by the rational structure screening of various ThDP‐dependent enzymes ...
Xiaoyang Chen   +6 more
openaire   +2 more sources

Intramolecular functionalisation by a methylene radical of a 1,2-diol and a vicinal amino alcohol: models for coenzyme B12-dependent diol dehydratase and ethanolamine ammonia lyase

Journal of the Chemical Society, Perkin Transactions 1, 2000
Coenzyme B12-dependent diol dehydratase converts 1,2-diols (e.g. propane-1,2-diol) into the corresponding aldehyde and water. The similar enzyme ethanolamine ammonia lyase transforms vicinal aminoalcohols (e.g. 2-aminoethanol) into the corresponding aldehyde and ammonia.
Andersen RJ   +3 more
openaire   +2 more sources

Benzaldehyde Lyase-catalyzed intramolecular benzoin reactions

2016
Intramolecular stereoselective carboligations are important reactions in organic synthetic chemistry essential for the access of natural occurring compounds and analogues. Besides the chemical methodologies, a plethora of intramolecular C-C bond forming reactions exists in different metabolic pathways of living organism catalyzed by highly evolved ...
Hernández Sánchez, Karel   +7 more
openaire   +1 more source

Progress in Stereoselective Construction of C–C Bonds Enabled by Aldolases and Hydroxynitrile Lyases

Frontiers in Bioengineering and Biotechnology, 2021
Jian-Bo Wang, Mi Liu, Wang Jian-Bo
exaly  

Hydroxynitrile lyases: At the interface of biology and chemistry

Enzyme and Microbial Technology, 2005
Tek Chand Bhalla, Mónica Sharma
exaly  

Crystallization and preliminary X-ray analysis of alginate lyases A1-II and A1-II′ fromSphingomonassp. A1

Acta Crystallographica Section F: Structural Biology Communications, 2005
Wataru Hashimoto   +2 more
exaly  

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