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Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase

Angewandte Chemie, 2021
AbstractThe reliable design and prediction of enzyme promiscuity to access transformations not observed in nature remains a long‐standing challenge. Herein, we present the first example of an intramolecular stereoselective Stetter reaction catalyzed by benzaldehyde lyase, guided by the rational structure screening of various ThDP‐dependent enzymes ...
Xiaoyang Chen   +6 more
openaire   +2 more sources

Intramolecular functionalisation by a methylene radical of a 1,2-diol and a vicinal amino alcohol: models for coenzyme B12-dependent diol dehydratase and ethanolamine ammonia lyase

Journal of the Chemical Society, Perkin Transactions 1, 2000
Coenzyme B12-dependent diol dehydratase converts 1,2-diols (e.g. propane-1,2-diol) into the corresponding aldehyde and water. The similar enzyme ethanolamine ammonia lyase transforms vicinal aminoalcohols (e.g. 2-aminoethanol) into the corresponding aldehyde and ammonia.
Andersen RJ   +3 more
openaire   +2 more sources

High-throughput in-field bioprospecting for cyanogenic plants and hydroxynitrile lyases

Biocatalysis and Biotransformation, 2020
Ruth Birner-Gruenberger   +2 more
exaly  

A Single Residue Influences the Reaction Mechanism of Ammonia Lyases and Mutases

Angewandte Chemie - International Edition, 2009
Sebastian Bartsch, Uwe T Bornscheuer
exaly  

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