Results 231 to 240 of about 1,075,882 (382)

XPC Deficiency Activate Cisplatin‐Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1‐Mediated Ubiquitination of the p53 Protein

Advanced Science, EarlyView.
This study reveals that XPC regulates autophagy signaling beyond its noncanonical DNA repair role, uncovering the XPC‐p‐ATM‐KDM4A‐PHRF1 axis as a novel mechanism for autophagy modulation under DNA damage stress. It identifies PHRF1 as a novel p53 ubiquitin ligase.
Baixiong Zhao, Yaqin Huang, Jiazhong Shi, Xiaozhou Zhou, Johan Bourghardt Fagman, Liwei Wang, Sha Liu, Wuxing Wang, Yuting Liu, Zhiwen Chen, Jin Yang   +10 more
wiley   +1 more source

Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies. [PDF]

World J Clin Oncol
Framarini M, D'Acapito F, Lippolis PV, Di Giorgio A, Di Pietrantonio D, Sommariva A, Sammartino P.   +6 more
europepmc   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Revisiting intraperitoneal chemotherapy for advanced high-grade serous ovarian cancer. [PDF]

Int J Gynaecol Obstet
Cheruvathur JS, Levin G, Ribeiro R, Racovitan F, Power J, Zeng X, Sampalis J, Gilbert L.   +7 more
europepmc   +1 more source

Perioperative Management for Colorectal Peritoneal Metastases [PDF]

, 2018
Kim, Bradford J., Passot, Guillaume
core   +1 more source

Health Related Quality of Life after Interval Cytoreductive Surgery with or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients with Stage III Ovarian Cancer

, 2018
Simone N. Koole, Jacobien M. Kieffer, Karolina Sikorska, Jules H. Schagen van Leeuwen, Henk W.R. Schreuder, Ralph H.M. Hermans, Ignace H. J. T. de Hingh, Jacobus van der Velden, Henriëtte J.G. Arts, Maaike van Ham, Arend G. J. Aalbers, Victor J. Verwaal, Koen Van de Vijver, Gabe S. Sonke, Willemien J. van Driel, Neil K. Aaronson   +15 more
openalex   +1 more source

Efficacy and safety in the use of intraperitoneal hyperthermia chemotherapy and peritoneal cytoreductive surgery for pseudomyxoma peritonei from appendiceal neoplasm: A systematic review

, 2022
Idevaldo Floriano, Antônio Silvinato, João Conrado Bueno dos Reis, Claudia Cafalli, Wanderley Marques Bernardo   +4 more
openalex   +1 more source

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial.

The Lancet Gastroenterology and Hepatology, 2019
C. Klaver, D. D. Wisselink, C. Punt, P. Snaebjornsson, J. Crezee, A. Aalbers, A. Brandt, A. Bremers, J. Burger, H. Fabry, F. Ferenschild, S. Festen, W. V. van Grevenstein, P. Hemmer, I. D. de Hingh, N. Kok, G. Musters, L. Schoonderwoerd, J. Tuynman, A. V. D. van de Ven, H. V. van Westreenen, M. Wiezer, D. Zimmerman, A. V. van Zweeden, M. Dijkgraaf, P. Tanis   +25 more
semanticscholar   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

The Effect of Induced Hypothermia on Postoperative Outcomes Following Hyperthermic Intraperitoneal Chemotherapy: A Negative Finding. [PDF]

Ther Clin Risk Manag
Yang MC, Lin KL, Chung KC, Chou SE, Chien M, Hsu CY.   +5 more
europepmc   +1 more source