Results 171 to 180 of about 58,052 (292)

The production of malignant tumors of the lung and pleura in dogs from intratracheal asbestos instillation and cigarette smoking [PDF]

open access: bronze, 1981
Edward W. Humphrey   +6 more
openalex   +1 more source

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2‐Mediated FOXP2 Transcriptional Binding Inhibition

open access: yesAging Cell, Volume 24, Issue 10, October 2025.
Smoking is one of the major causes of pulmonary fibrosis (PF), and treatment options for PF are limited. We show that POT1 is decreased in PF patients and mice, especially in smoke exposure, and investigate its contributions to PF progression from protecting AT2 cell senescence to fibrosis. AAV9‐mediated restoration of POT1 prevents PF.
Mengkun Shi   +9 more
wiley   +1 more source

Zerumbone Attenuates Lipopolysaccharide‐Induced Acute Lung Injury by Suppressing the NLRP3/Caspase‐1/GSDMD Signalling Pathway

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT A cyclic sesquiterpene with 11 carbon atoms is the primary component of essential oils from the wild ginger species, Zingiber zerumbet. It exhibits pharmacological effects, including anti‐inflammatory and antioxidant properties. However, limited information exists regarding its role in pyroptosis during acute lung injury (ALI).
Yun‐Jie Xu   +7 more
wiley   +1 more source

Deliberating the scientific evidence base for influenza transmission to raw milk consumers

open access: yesRisk Analysis, Volume 45, Issue 10, Page 2939-2955, October 2025.
Abstract Transmission of influenza A H5N1, commonly known as avian influenza or bird flu, from wild birds to cows on 1073 large US dairy farms in 17 states, and from cows to 41 dairy workers in five states, has raised concerns about limited evidence for transmission routes.
Margaret E. Coleman
wiley   +1 more source

CYP1B1 Mediates Cigarette Smoke–Induced Lipid Accumulation in Alveolar Type 2 Cells

open access: yesThe FASEB Journal, Volume 39, Issue 18, 30 September 2025.
Scheme of cigarette smoke (CS)‐induced lipid accumulation in alveolar type 2 (AT2) cells. Cigarette smoke (CS) exposure induces the expression of cytochrome P450 family 1 subfamily B member 1 (CYP1B1) by disrupting lipid metabolism in AT2 cells. The upregulation of CYP1B1 contributes to lipid accumulation within AT2 cells, leading to elevated oxidative
Yin Zhu   +6 more
wiley   +1 more source

Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations. [PDF]

open access: yesCrit Care Explor
Kuhar E   +11 more
europepmc   +1 more source

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