Results 171 to 180 of about 76,183 (332)

Ligation of protease-activated receptor 1 enhances alpha(v)beta(6) integrin-dependent TGF-beta activation and promotes acute lung injury [PDF]

open access: yes, 2006
Activation of latent TGF-beta by the alpha(v)beta(6) integrin is a critical step in the development of acute lung injury. However, the mechanism by which a alpha(v)beta(6)-mediated TGF-beta activation is regulated has not been identified.
Camerer, E   +9 more
core  

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu   +17 more
wiley   +1 more source

Novel Humanized Mouse Model for Steroid‐Resistant Asthma

open access: yes
Allergy, EarlyView.
Shiho Yamada   +9 more
wiley   +1 more source

Invasive Pseudomembranous Aspergillus Tracheobronchitis Accompanied With Fever and Hemoptysis: A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Pseudomembranous Aspergillus tracheobronchitis is a relatively rare disease, and it is very easy for clinicians to misdiagnose. It is particularly necessary for the patient presenting with recurrent pyrexia and hemoptysis in the absence of clear‐cut pulmonary radiological findings to receive a bronchoscopy.
Xiaolong Li   +5 more
wiley   +1 more source

Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome

open access: yesMedComm, Volume 6, Issue 9, September 2025.
In quiescent PECs, Eno1 binds to the 3′ UTR of CXCL12 mRNA to prevent translation. Following activation, lactate is accumulated and then mediates an increase in lysine lactylation. Eno1, a substrate in this modification, releases bound CXCL12 mRNA upon lactylation to promote translation. Meanwhile, the activity of Eno1 as a glycolytic enzyme increases,
Xu Liu   +5 more
wiley   +1 more source

Pharmacokinetics of Gentamicin Administered Intratracheally to Rats [PDF]

open access: bronze, 1978
T. Trnovec   +6 more
openalex   +1 more source

Phytosphingosine Alleviates Cigarette Smoke‐Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4

open access: yesMedComm, Volume 6, Issue 9, September 2025.
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a complex and irreversible respiratory disorder with a poor prognosis and a lack of effective pharmaceutical treatment. Our previous metabolomics study identified phytosphingosine (PHS) as a key differential metabolite in COPD that is positively correlated with lung function.
Yuan Zhan   +13 more
wiley   +1 more source

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