Results 101 to 110 of about 9,756 (290)

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Sudden Sensorineural Hearing Loss in an Immunocompetent Patient With West Nile Encephalitis

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Objective Sudden sensorineural hearing loss (SSNHL) is a frequently encountered condition that is often idiopathic but may be precipitated by infection. Neuroinvasive disease resulting from West Nile virus (WNV) is a rare cause of SSNHL, typically affecting immunocompromised patients and generally associated with minimal hearing recovery.
Raj Malhotra, Barrie Schmitt, Ken Tyler, Yuri Agrawal   +3 more
wiley   +1 more source

Editorial: Intratympanic and surgical treatment for Meniere's disease

Frontiers in Neurology, 2022
Jun Yang, Jun Yang, Jun Yang, Yupeng Liu, Yupeng Liu, Yupeng Liu, Maoli Duan, Maoli Duan   +7 more
doaj   +1 more source

Ongoing Discrepancy Between Unilateral Meniere's Disease and Bilateral Endolymphatic Hydrops on Hydrops MRI

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Objective In the era of Hydrops MRI, a clinical dilemma has emerged: while Meniere's disease (MD) is diagnosed unilaterally, Hydrops MRI demonstrates endolymphatic hydrops (EH) bilaterally. This study aims to clarify this ongoing discrepancy. Methods Fifty‐six MD patients underwent an inner ear test battery followed by 3 T Hydrops MRI.
Ting‐Hua Yang, Ling‐Chen Meng, Yi‐Ho Young   +2 more
wiley   +1 more source

Hipoacusia neurosensorial súbita. Infiltración corticoidea intratimpánica [PDF]

, 2009
La hipoacusia neurosensorial súbita es una urgencia otorrinolaringológica. Precisa de un diagnóstico y tratamiento precoz para permitir la máxima recuperación auditiva del paciente. En la mayoría de los casos es de etiología idiopática.
Bejarano-Panadés, Natalia, Sarría Echegaray, Pedro, Tomás Barberán, Manuel   +2 more
core  

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Efficacy of Intratympanic Steroid Injection in Resistant Sudden Sensorineural Hearing Loss with Failure of Systemic Therapy

مجله دانشکده پزشکی اصفهان, 2009
Background: Intratympanic steroid injection is an effective method in treatment of sudden sensorineural hearing loss in cases resisted to systemic therapy. The purpose of this study was to determine the efficacy of intratympanic injection.
Seyed Mostafa Hashemi, Mehrdad Roghae, Susan Miralahi, Abdolreza Nakhaei, Ali Reza KHodami   +4 more
doaj  

Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus

The Egyptian Journal of Otolaryngology, 2019
Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride ...
Tamer A. Abo El Ezz, Fathy N. Fattoh, Tahany Rabie   +2 more
doaj   +1 more source

Current strategies for drug delivery to the inner ear

Acta Pharmaceutica Sinica B, 2013
For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery ...
Hongzhuo Liu, Jinsong Hao, Kevin S. Li
doaj   +1 more source