Results 81 to 90 of about 9,756 (290)
Otology and Neurotology, 2021 Supplemental Digital Content is available in the text Objective: To evaluate the safety and exploratory efficacy of intratympanic administration of OTO-313 in patients with tinnitus.
K. Maxwell +8 more
semanticscholar +1 more source
Systemic effects of intratympanic dexamethasone therapy [PDF]
Endocrine Connections, 2014 ObjectiveThe study aimed to assess the possible systemic effects of intratympanic dexamethasone (IT-Dex) on the hypothalamic–pituitary–adrenal (HPA) axis, inflammation, and bone metabolism.DesignA prospective cohort study including 30 adult patients of a tertiary referral ENT clinic treated with 9.6 mg IT-Dex over a period of 10 days was carried out ...
Novoa, Eva +2 more
openaire +2 more sources
Med Research, Volume 1, Issue 3, Page 322-358, December 2025.ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin +8 more
wiley +1 more source
Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study. [PDF]
, 2011 The aim of this study was to verify the efficacy and the safety of transtympanic dexamethasone to treat sudden sensorineural hearing loss as first and single drug method. Considering ethical implication of performing a mininvasive procedure on middle
AMODIO, Emanuele +6 more
core +1 more source
Possibilities of Inner Ear Barrier Models for Otologic Drug Development
Advanced Therapeutics, Volume 8, Issue 11, November 2025.This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn +7 more
wiley +1 more source
Bengal Journal of Otolaryngology and Head Neck Surgery, 2017 Introduction Steroid therapy is considered to be the gold standard for sudden sensorineural hearing loss (SSNHL). Delivering steroids by intratympanic injection is more efficient than systemic injections with minimum or no side effects.
Mukul Patar, Rupanjita Sangma
doaj +3 more sources
Intratympanic corticosteroid for sudden hearing loss: does it really work?
Brazilian Journal of OtorhinolaryngologyINTRODUCTION: Sudden deafness is characterized by an abrupt hearing loss of at least 30 dB in three sequential frequencies in the standard pure tone audiogram over three days or less.
Monique Antunes de Souza Chelminski Barreto +3 more
doaj +1 more source
Therapeutic Effect of Intratympanic Injection of Dexamethasone plus Hyaluronic Acid on Patients with Meniere's disease [PDF]
Iranian Journal of Otorhinolaryngology, 2019 Introduction: Intratympanic therapy, as a widely used treatment for inner ear diseases, is regarded as a therapeutic method in controlling the vertigo of the patients with Meniere’s disease.
Mehrdad Rogha +6 more
doaj +1 more source
Vestibular schwannoma and ipsilateral endolymphatic hydrops: an unusual association [PDF]
, 2017 Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual nding that may lead clinicians to errors and delays in ...
ALTISSIMI, Giancarlo +8 more
core +2 more sources
Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives
Advanced Science, Volume 12, Issue 44, November 27, 2025.Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley +1 more source