Results 121 to 130 of about 74,108 (188)

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

Food Frontiers, Volume 7, Issue 5, September 2026.
We developed a macrophage‐derived exosome‐based delivery system to enhance the therapeutic efficacy of puerarin (Pue) against atherosclerosis (AS). Exosomes were isolated from RAW264.7 cells, co‐cultured with Pue, and comprehensively characterized for morphology, stability, and drug loading.
Zijian Zou, Liangxing Tu, Ye Yang, Jianfang Feng, Yi Jin, Ruyue Yang, Meng Cheng   +6 more
wiley   +1 more source

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Bioengineered Extracellular Vesicles Mitigate Neuroinflammation by Neutralizing Pneumolysin and Delaying Disease Onset in Experimental Pneumococcal Meningitis

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Bacterial meningitis is a life‐threatening neurological disorder frequently caused by a Streptococcus pneumoniae (the pneumococcus) infection of the brain. Standard treatment consists of antibiotics to eliminate bacteria and dexamethasone to reduce inflammation.
Kristine Farmen, Doste R. Mamand, Miguel Tofiño‐Vian, Georgia Yfanti, Xiuming Liang, Houze Zhou, Vicky W. Q. Hou, Samir El Andaloussi, Oscar P. B. Wiklander, Federico Iovino   +9 more
wiley   +1 more source

Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Pegcetacoplan in Patients with Paroxysmal Nocturnal Hemoglobinuria

Drugs in R&D
Background and Objective Paroxysmal nocturnal hemoglobinuria is a rare blood disorder characterized by life-threatening hemolysis and thrombosis. Complement C5 inhibitor therapy improves symptoms and life prognosis; however, it can result in insufficient
Ryan L. Crass, Brandon Smith, Sven Adriaens, Sunny Chapel, Grant Langdon   +4 more
doaj   +1 more source

Cerebral Blood Transit in Sickle Cell Anemia

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 738-750, September 2026.
ABSTRACT Background Sickle cell anemia (SCA) patients upregulate cerebral blood flow to compensate for decreased arterial oxygen content. Such hyperemic conditions can manifest as venous hyperintense signal on arterial spin labeling (ASL) MRI, which may reflect faster capillary blood transit, altered oxygen extraction fraction (OEF), and infarct risk ...
Wesley T. Richerson, Megan A. Aumann, Alexander K. Song, Samantha Davis, Lauren Milner, Maria Garza, Dann Martin, L. Taylor Davis, Sumit Pruthi, Lori C. Jordan, Manus J. Donahue   +10 more
wiley   +1 more source

Intravascular Hemolysis and AKI in Children Undergoing Extracorporeal Membrane Oxygenation. [PDF]

Kidney360, 2023
Strong AE, Zee J, Fulchiero R, Kilbaugh TJ, Connelly J, Makeneni S, Campos D, Laskin BL, Denburg MR.   +8 more
europepmc   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Babesia microti Causing Intravascular Hemolysis in Immunocompetent Child, China. [PDF]

Emerg Infect Dis, 2023
Yao J, Liu G, Zou Y, Jiang J, Li S, Wang H, Cheng X, Zhang R, Zhang K, Wei C, Wu R.   +10 more
europepmc   +1 more source

Peroxynitrite‐induced structural remodeling and aggregation of hemoglobin under nitroxidative stress

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Peroxynitrite (PN), generated by the reaction of nitric oxide with superoxide, is a potent reactive nitrogen species (RNS) implicated in nitroxidative protein damage in cardiovascular and neurodegenerative diseases. Hemoglobin (Hb), the principal oxygen‐transport protein of erythrocytes, is a key intravascular scavenger and target of PN ...
Shaik Basha, Aradhika Vijeev, Darshan Chikkanayakanahalli Mukunda, Krishna Kishore Mahato   +3 more
wiley   +1 more source

Perioperative Changes in Blood Volume and Fluid Distribution in Total Hip Arthroplasty—A Protocol for a Prospective Single‐Center Observational Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Surgical stress response initiates a complex pathophysiological cascade that alters fluid distribution and intravascular volume. In elective total hip arthroplasty (THA), the perioperative blood loss is potentially substantial, a significant part of the loss being hidden caused by tissue extravasation, residual joint blood, and ...
Puk Kristiansen, Nicolai Bang Foss, Kirill Gromov, Anders Troelsen, Ana‐Marija Hristovska   +4 more
wiley   +1 more source